柴芍承气汤联合乌司他丁对重症急性胰腺炎及其并发症的临床疗效分析

Clinical Effect of Chaishao Chengqi Decoction Combined with Ulinastatin for Severe Acute Pancreatitis and Its Complication Analysis

目的:探讨柴芍承气汤联合乌司他丁对重症急性胰腺炎(SAP)及其并发症的临床疗效。方法:64例符合纳入标准的SAP患者按随机数字表格法分为对照组和观察组,各32例。两组患者均给予对症支持的常规治疗,对照组加用乌司他丁;观察组在对照组的基础上加用柴芍承气汤,疗程7天。结果:观察组有效率为96.9%,明显高于对照组的78.1%,差异具有统计学意义(P<0.05);腹痛、胰腺水肿消失时间及首次主动排便时间均明显减少(P<0.05);血尿淀粉酶及白细胞计数恢复时间也明显缩短(P<0.05);并发症与死亡的发生率明显降低(P<0.05)。结论:大承气汤与乌司他丁联用对SAP疗效确切,可降低SAP治疗过程中或治疗后并发症的发生率及死亡率,具有重要临床意义。

Objective： To investigate the clinical efficacy Chaishao Chengqi decoction combined with ulinastatin in the treatment of severe acute pancreatitis（ SAP） and its complications. Methods： 64 patients with SAP were randomly divided into a control group and an observation group,32 cases in each group. Patients in two groups were given conventional treatment. The control group was treated with ulinastatin; observation group was on the basis of the control group plus Chaishao Chengqi decoction,with the treatment for 7d. Results： The effective rate was 96. 9% in observation group,significantly higher than 78. 1% in control group,and the difference was statistically significant（ P ＆lt; 0. 05）. Abdominal pain,pancreatic edema disappeared and for the first time the initiative defecation was significantly reduced（ P ＆lt; 0. 05）; Urine amylase and white blood cell count were significantly shorter recovery time（ P ＆lt; 0. 05）; incidence of complications and mortality was significantly lower（ P ＆lt; 0. 05）. Conclusion： Chaishao Chengqi decoction combined with ulinastatin has a curative effect on SAP,and the incidence of complications and mortality are reduced and the difference has an important clinical significance.