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慢性应激对大鼠主动脉ET-1、eNOS表达的影响及电针的干预作用 被引量:3

Alteration of ET- 1 and eNOS in Aorta Tissue with Chronicity Stress Depression Model Rats and Effect of Electro- acupuncture
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摘要 目的:观察慢性应激对SD大鼠主动脉ET-1、eNOS表达的影响以及电针的干预作用,探讨抑郁症与心血管疾病之间的关系。方法:采用慢性应激刺激结合孤养的方式建立大鼠慢性应激抑郁模型,分组后分别采用电针、氟西汀治疗21天,光镜观察大鼠胸主动脉形态学变化,免疫组化法(S-P)测定主动脉ET-1、eNOS表达。结果:HE染色显示,模型组大鼠主动脉组织损伤,针刺干预可以改善此损伤;模型组大鼠主动脉组织ET-1高度表达、eNOS表达降低,电针和氟西汀均可改善变化。结论:慢性应激可引起大鼠的血管内皮结构和功能的损伤,电针和氟西汀可改善这些变化。 Objective: To observe the changes of ET - 1 and eNOS in aorta tissue with chronicity stress depres- sion model rats and the interference of electroacupuncture on them, and to explore the function of the renin - angiotensin system between depression and cardiovascular disease. Methods:The chronic unpredictable mild stress combined with solitarily feeding method was used to make the depression models. The morphological changes of thoracic were observed with light microscope. Immunohistochemistry method was applied to analyze the expres- sion of Endothelin 1 ( ET - 1 ) and Endothelial nitric oxide synthase (eNOS). Results : The endothelium of model rats was damaged. Electro - acupuncture could improve those changes. The expression of ET - 1 in the arterial tissue of model rats enhanced. The expression of eNOS in the arterial tissue of model rats reduced. Electro - acupuncture and fluoxetine were obvious to improve those changes. Conclusion:Local tissue RAS is activated excessively in chronicity stress depression model rats. Electro- acupuncture and fluoxetine can improve those changes
出处 《针灸临床杂志》 2014年第4期64-66,F0003,共4页 Journal of Clinical Acupuncture and Moxibustion
基金 国家自然基金项目 编号:81072860
关键词 抑郁 电针 血管内皮功能 Depression Electro - acupuncture Vascular endothelial function
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参考文献9

  • 1季康,黄捷英,沈潞华.冠心病患者的心理评估及心理干预[J].北京医学,2005,27(2):69-71. 被引量:16
  • 2Cankurtaran M, Halil M, Yavuz BB,et al. Depression and concomitant diseases in a Turkish geriatric outpatient setting [ J ]. Arch Gerontol Geriatr,2005,40 ( 3 ) : 307 - 315.
  • 3Ruo B, Bertenthal D, Sen S, et al. Self - rated health among women with coronary disease: depression is as important as recent cardiovas- cular events[J]. Am Heart J,2006,152(5 ) :921. e1-7.
  • 4Mulvihill NT, Foley JB. Inflammation in acute coronary syndromes [ J ]. Heart, 2002,87 ( 3 ) :201 - 204.
  • 5Penna C, Rastaldo R, Mancardi D, et al. Effect of endothelins on the eardiovascular system [ J ]. J Cardiovasc Med ( Hagerstown ) , 2006,7 (9) :645 -652.
  • 6刘艳,杨解人,郝伟,张俊秀,唐丽娟,陈国祥.复方山菊对自发性高血压大鼠主动脉损伤的保护作用及机制[J].中国临床药理学与治疗学,2013,18(7):732-737. 被引量:1
  • 7吴淳淳,杜心清.内皮型一氧化氮合酶与冠心病的研究进展[J].医学综述,2013,19(10):1756-1758. 被引量:9
  • 8Smoller JW, Allison M, Cochrane BB, et al. Antidepressant use and risk of incident cardiovascular morbidity and mortality among postm- enopausal women in the Women's Health Initiative study[ J]. Arch Intern Med ,2009,169 (22) :2128 - 2139.
  • 9Whang W, Kubzansky LD, Kawachi 1, et al. Depression and risk of sudden cardiac death and coronary heart disease in women: results from the Nurses' Health Study [ J ]. J Am Coll Cardiol, 2009,53 ( 11 ) : 950 -958.

二级参考文献49

  • 1隋辉,王文,王佩合,李悦.抗氧化剂ebselen对SHRsp冠状动脉eNOS蛋白表达的影响[J].中国临床药理学与治疗学,2005,10(2):141-144. 被引量:2
  • 2张忠,程富胜,张霞,高芳,孟聚诚,贾宁.野菊花提取物对小鼠血清NO、NOS的影响[J].中兽医医药杂志,2006,25(1):21-22. 被引量:15
  • 3姜伟,张丽.钩藤的药理作用研究[J].现代中西医结合杂志,2006,15(21):3013-3015. 被引量:46
  • 4Sirois BC, Burg MM. Negative emotion and coronary heart disease.Behav Modif, 2003, 27:83 - 102.
  • 5Hance M, Carney RM, Freedland KE, et al. Depression in patients with coronary heart disease: a 12-month follow-up. Gen Hosp Psychiatry, 1996, 18:61 - 65.
  • 6Glassman AH, Shapiro PA. Depression and the course of coronary artery disease. Am J Psychiatry, 1998, 155:4- 11.
  • 7Musselman DL, Evans DL, Nemeroff CB. The relationship of depression to cardiovascular disease: epidemiology, biology and treat-ment.Arch Gen Psychiatry, 1998, 55:580 - 592.
  • 8Linden W, Stossel C, Maurice J. Psychosoail interventions for patients with coronary artery disease; a meta-analysis. ArchInternMed, 1996,156:745 -52.
  • 9Beresnevaite M. Exploring the benefits of group psychotherapy in reducing alexithymia in coronary heart disease patients: a preliminary study.Psychother Psychosom, 2000, 69:117 - 122.
  • 10Pratt LA, Ford DE, CrumRM, et al.Depression,psychotropic medication, and risk of myocardial infarction.Circulation, 1996, 94: 3123 -3129.

共引文献23

同被引文献63

  • 1何利雷,闫兵,罗任,邵瑛,唐纯志.电针对血管性痴呆大鼠学习记忆能力及血浆TXB_2和6-keto-PGF_(1α)含量的影响[J].上海针灸杂志,2007,26(4):44-46. 被引量:17
  • 2Alesci S, Martinez P E, Kelkar S, et al. Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab, 2005, 90(5): 2522-2530.
  • 3Grippo A J, Johnson A K. Stress, depression, and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preelinical disease models. Stress, 2009, 12(1): 1-21.
  • 4Danesh J, Kaptoge S, Mann A C. Set a long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospectivestudies and a systematic review. PLoS Med, 2008, 5(4): 78.
  • 5Pizzi C, Manzoli L, Mancini S, et al. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J, 2008, 29(9): 1110-1117.
  • 6Rugulies R. Depression as a predictor for coronary heart disease. A review and meta-analysis. Am JPrev Med, 2002, 23 (1): 51-61.
  • 7Wulsin L R, Singal B M. Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med, 2003, 65 (2): 201-210.
  • 8Meijer A, Conradi H J, Bos E H, et al. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis of 25 years of research. Gen Hosp Psychiatry, 2011, 33(3): 203-216.
  • 9Fuster V, Falk E, Fallon J T, et al. The three processes leading to post PTCA restenosis:dependence on the lesion substrate. Thromb Haemost, 1995, 74: 552-559.
  • 10Mosovich S A, Boone R T, Reichenberg A, et al. New insights into the link between cardiovascular disease and depression, lnt J Clin Pract, 2008.62(3): 423-432.

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