胎儿大脑中动脉血流峰速值对地中海贫血的诊断价值

Diagnostic value of ultrasonic measurement of fetal middle cerebral artery blood flow predict fetal thalasse-mia

目的：探讨多普勒超声检测胎儿大脑中动脉血流峰值速度对预测胎儿地中海贫血的临床价值。方法选取在产前检查夫妻双方为轻型或中间型地中海贫血患者90例的单胎孕妇为观察对象，同时选取同期接受多普勒超声检查的夫妻双方均无地中海贫血基因的单胎孕妇作对照组，统计两组孕妇在（22．0±3．0）孕周胎儿大脑中动脉血流动力学相关指标。结果重型地中海贫血胎儿大脑中动脉血流峰值速度平均为（52．06±11．03）cm/s，与对照组相比，差异有统计学意义（χ2＝348．20，P＜0．01），而重型地中海贫血胎儿博动指数、阻力指数及S/D与对照组相比，χ2分别为1．35、0．49、0．91，P均＞0．05，差异无统计学意义；轻型与中间型地中海贫血胎儿大脑中动脉血流峰值速度与对照组相比，χ2分别为1．63、5．79，P＞0．05，差异无统计学意义。结论多普勒超声测量胎儿大脑中动脉收缩期峰值速度预测地中海贫血有效、可靠、无创、可重复，拥有广泛的应用前景。

Objective To study the Doppler ultrasound measurement of fetal middle cerebral artery peak ve -locity in the prediction of fetal thalassemia clinical value .Methods 90 cases of singleton pregnancies who were diag-nosesed for light or thalassemia intermedia patients ,also including her spouse were selected as the observation group , while in the same period in our hospital ,pregnant women of singleton pregnancy detected by Doppler ultrasound who had had no thalassemia gene ,also including her spouse were selected as control group .Gestation fetal brain hemody-namics related indicators of （22.0 ±3.0）weeks were analyzed for both groups .Results The thalassemia fetal middle cerebral artery peak velocity averaged （52.06 ±11.03）cm/s,compared with the control group ,the difference was sig-nificant（χ2 =348.20,P＆lt;0.01）,but there were no significant differences in thalassemia fetus Pollex index ,resistance index and S/D（χ2=1.35,0.49,0.91,all P〉0.05）;Light with thalassemia intermedia fetal middle cerebral artery peak ve-locity had no significant difference compared with control group （χ2 =1.63, 5.79, P 〉0.05 ）.Conclusion Doppler ultrasound used to detect fetal middle cerebral artery peak systolic velocity prediction thalassemia has the ad -vantages of valid,reliable,non-invasive,repeatable,which has broad application prospects .