高压氧在难治性消化性溃疡治疗中的应用

Application of hyperbaric oxygen in the treatment of refractory peptic ulcer

目的：探讨高压氧（ HBO）在难治性消化性溃疡治疗中的应用效果。方法回顾性分析259例难治性消化性溃疡患者的临床资料，根据是否行HBO治疗将患者分为高压氧组（127例）和对照组（132例）。比较两组总有效率、幽门螺杆菌（ Hp）根除率和复发率。结果高压氧组总有效率、Hp根除率分别为93．7％、92．1％，明显高于对照组的65．2％、56．1％（χ^2＝31．97，7．32，均P＜0．05）；高压氧组复发率为8．4％，明显低于对照组的33．3％（χ^2＝12．51，P＜0．05）。结论高压氧联合药物治疗难治性消化性溃疡具有更好的疗效。

Objective To explore the application effect of hyperbaric oxygen （ HBO ） in the treatment of refractory peptic ulcer .Methods Clinical data of 259 patients with refractory peptic ulcer were retrospectively ana-lyzed.According to whether received HBO therapy , these patients were divided into the HBO group （ n=127 ） and control group（n=132）.The total effective rate,Helicobacter pylori（Hp） eradication rate and relapse rate of the two groups were compared .Results The total effective rate ,Hp eradication rate of the HBO group were 93.7%,92.1%, respectively,which were significantly higher than 65.2%,56.1% of the control group （χ2 =31.97,7.32,all P〈0.05）.The relapse rate of the HBO group was 8.4%,which was significantly lower than 33.3%of the control group （χ^2 =12.51,P〈0.05）.Conclusion HBO combined with conventional drug in the treatment of refractory peptic ulcer has significant effect .