自拟补阳回神散联合高压氧在急性一氧化碳中毒后迟发性脑病治疗中的应用

Application of Buyanghuishensan plus hyperbaric oxygen in the treatment of delayed encephalopathy after acute carbon monoxide poisoning

目的：探讨自拟补阳回神散联合高压氧治疗急性一氧化碳中毒后迟发性脑病的疗效。方法143例急性一氧化碳中毒后迟发性脑病按照数字表法随机分为两组。对照组70例采用西药联合高压氧治疗，治疗组73例采用自拟补阳回神散联合高压氧及西药治疗。治疗3个月比较两组疗效、简易精神状态检查法（MMSE）和日常生活能力表（ADL）神经功能评分。结果治疗组总显效率为97．3％，明显优于对照组的88.6％（χ^2＝4.84，P＜0．05）。治疗3个月后两组MMES均有明显升高（t＝3．096、4．725，均P＜0．01），且治疗组升高更明显（t＝2．466，P＜0．05）。治疗3个月后两组ADL均有明显降低（t＝2．691、3．179，P＜0．05， P＜0．01），且治疗组降低更明显（t＝2．607，P＜0．05）。结论自拟补阳回神散联合高压氧治疗急性一氧化碳中毒后迟发性脑病可以明显改善神经功能，提高临床疗效。

Objective To explore the effect of Buyanghuishensan plus hyperbaric oxygen and medicine in the treatment of delayed encephalopathy after acute carbon monoxide poisoning .Methods According to the digital t able,143 patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into two groups .70 patients in the control group were treated by hyperbaric oxygen and medicine ,while 73 patients in the treat-ment group were treated by Buyanghuishensan plus hyperbaric oxygen and medicine .They were treated for three months.After three months,MMSE and ADL were used to determine changes of the patients＆#39;neurological function. Results The total effective rate of the treatment group was 97.3%,which was significantly higher than 88.6%in the control group（χ2 =4.84,P〈0.05）.After treatment for 3 months,the MMES score of the two groups increased signif-icantly （t=3.096,4.725,all P〈0.01）,and that of the treatment group increased more significantly （t=2.466,P〈0.05）.After treatment for 3 months,the ADL score of the two groups decreased significantly （t=2.691,3.179,P〈0.05 or P〈0.01）,and that of the treatment group decreased more significantly （t=2.607,P〈0.05）.Conclusion Buyanghuishensan plus hyperbaric oxygen and medicine can improve neurological function in patients with delayed encephalopathy after acute carbon monoxide poisoning .