重组人生长激素在重度烧伤治疗中的临床应用价值

Clinical application value of recombinant human growth hormone in the treatment of severe burns

目的：探讨重组人生长素（ rhGH）在重度烧伤治疗中的应用价值。方法将36例重度烧伤患者按数字表法随机分为观察组和对照组，每组18例。两组均应用同样的抗感染治疗、营养支持及外科手术方法，治疗组给予rhGH皮下注射治疗，对照组每天注射等量的0．9％氯化钠注射液。比较两组肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）的水平及创面愈合时间、住院时间等指标。结果两组治疗7 d、14 d后TNF-α水平和IL-6水平[（18．4±3．3）ng/L与（24．9±7．3）ng/L，（133．2±66．9）ng/L与（271．4±88．9）ng/L，（15.4±3．2）ng/L与（25．4±4．9） ng/L，（90．9±20．8） ng/L与（200．7±62．2） ng/L]差异均有统计学意义（t＝3．74、4．75、4．02、4．69，均P＜0．05）。观察组创面愈合时间和住院时间均显著短于对照组（t＝3．75、3.86、4．75、4．64，均P＜0．05）。结论 rhGH对重度烧伤患者伤口的愈合有很大促进作用，从而缩短了患者的住院时间，具有很好的临床效果。

Objective To investigate the application value of recombinant human growth hormone （ rhGH） in the treatment of severe burns .Methods 36 patients with severe burns were selected and randomly divided into the observation group and control group ,18 cases in each group .Both two groups used the same anti-infection therapy , nutritional support and surgical methods .The observation group received rhGH subcutaneous injection therapy , the control group used the same amount of daily injections of 0.9%sodium chloride.The levels of tumor necrosis factor-α（ TNF-α） and interleukin 6 （ IL-6 ） , wound healing time , hospitalization time and other indicators were compared between the two groups.Results 7d,14d after treatment,the TNF-αand IL-6 levels of the two groups were （18.4 ± 3.3）ng/L vs （24.9 ±7.3）ng/L,（133.2 ±66.9）ng/L vs （271.4 ±88.9）ng/L,（15.4 ±3.2）ng/L vs （25.4 ± 4.9）ng/L,（90.9 ±20.8） ng/L vs （200.7 ±62.2） ng/L,the differences were significant between the two groups （t=3.74,4.75,4.02,4.69,all P〈0.05）.The healing time and hospital stay in the observation group were signifi-cantly shorter than those of the control group （t=3.75,3.86,4.75,4.64,all P〈0.05）.Conclusion rhGH therapy can significantly improve the wound healing of severe burn patients ,reduce hospitalization time,it has good clinical results.