冠心病合并2型糖尿病患者N末端脑钠肽前体和D-二聚体的相关性

The correlation between N-terminal pro-brain natriuretic peptide and D-dimer in coronary artery disease pa-tients with type 2 diabetes

目的：探讨冠心病合并2型糖尿病患者血清中D-二聚体水平与N末端脑钠肽前体（ NT-porB-NP）的相关性。方法选取50例冠心病合并2型糖尿病患者作为研究组，并选取同期体检健康者30例为健康对照组。检测两组血清中 D-二聚体水平和 NT-porBNP 的含量水平，并经统计学分析两者的相关性。结果研究组血清中D-二聚体、NT-porBNP水平分别为（2．43±0．58）mg/L、（1487．8±201．5）pg/L，均高于健康对照组的（0．26±0．13）mg/L、（83．3±21．4）pg/L（t＝21．34、32．12，均P＜0．05）。 D-二聚体水平和NT-porBNP的含量水平呈明显正相关（r＝0.564，P＜0．05）。结论冠心病合并2型糖尿病患者血清中D-二聚体和NT-proBNP的含量水平密切相关，且高水平表达。

Objective To explore the correlation between N-terminal pro-brain natriuretic peptide （ NT-porB-NP） and D-dimer in coronary artery disease patients with type 2 diabetes .Methods 50 coronary heart disease patients with type 2 diabetes were selected as the study group ,and 30 healthy subjects at the same period were select-ed as the healthy control group .The serum levels of NT-porBNP and D-dimer were detected in two groups ,and the cor-relation between NT-porBNP and D-dimer was analyzed .Results The serum D-dimer and NT-porBNP levels in the study group were significantly higher than those in the control group [（2.43 ±0.58）mg/L vs （0.26 ±0.13）mg/L, （1 487.8 ±201.5）pg/L vs （83.3 ±21.4）pg/L]（t=21.34,32.12,all P〈0.05）.The D-dimer level was positively correlated with the NT-porBNP level （r=0.564,P〈0.05）.Conclusion In coronary heart disease patients with type 2 diabetes ,the serum levels of D-dimer and NT-proBNP are high and closely related .