注射用牛肺表面活性剂联合氨溴索治疗早产儿呼吸窘迫综合征180例疗效观察

Observation of the effect of pulmonary surfactant-associated proteins combined with ambroxol in the treat-ment of 180 children with congenital alveolar dysplasia neonatal respiratory distress syndrome

目的：观察牛肺表面活性剂（珂立苏）联合氨溴索对早产儿呼吸窘迫综合征（ NRDS）的治疗效果。方法将180例 NRDS患儿根据数字表法随机分为观察组和对照组，每组90例。两组均给予常规治疗，另外对照组给予氨溴索治疗，观察组在对照组治疗基础上加用珂立苏。比较两组疗效。结果与对照组治疗后比较，观察组患儿PaO2及pH值均升高，PaCO2值下降，其中两组PaO2及PaCO2值比较差异均有统计学意义（t＝5．91、13．16、29．89、2．98、5．11、8．13，均P＜0．05）；观察组机械通气时间、住院天数分别为（45．30±5.35）h、（10．01±2．24）d，均明显优于对照组的（68．27±6．13）h、（17．24±2．39）d（t＝26．78、20．94，均P＜0.05）。结论珂立苏联合氨溴索能明显改善NRDS患儿的缺氧症状，降低机械通气时间、住院天数，改善患儿预后。

Objective To observe the effect of pulmonary surfactant-associated proteins （ Kelisu） combined with ambroxol in the treatment of 180 congenital alveolar dysplasia children with neonatal respiratory distress syndrome （ NRDS） .Methods According to random number table ,180 congenital alveolar dysplasia children with NRDS were randomly divided into the observation group and control group , 90 cases in each group .In addition to conventional therapy,the control group was given ambroxol hydrochloride treatment ,the observation group was given Kelisu on thebasis of treatment of the control group.The treatment effect was compared between the two groups .Results Comparedwith the control group,after treatment the values of PaO2 and pH were significantly increased,PaCO2 significantly decreasedin the observation group（t =5.91,13.16,29.89,2.98,5.11,8.13,all P 〈0.05）.The duration of mechanicalventilation,length of hospital stay were （45.30 ±5.35）h,（10.01 ±2.24）d in the observation group,respectively,which were significantly better than[（68.27 ±6.13）h,（17.24 ±2.39）d]in the control group（t =26.78,20.94,all P 〈0.05）.Conclusion Kelisu combined with hydrochloride ambroxol can significantly improve hypoxia symp -toms in NRDS children,reduce the duration of mechanical ventilation and length of hospital stay ,improve the prognosis.