益气生血法联合同步放化疗治疗鼻咽癌35例

Yiqi Shengxue Soup Reduced the Adverse Effect of Concurrent Chemoradiation in Locally Advanced Nasopharyngeal Cancer Patients

目的:观察中医益气生血法对中晚期鼻咽癌放化疗疗效及不良反应的影响。方法:68例初治中晚期鼻咽癌患者随机分为2组,观察组(中药联合放化疗组)35例,对照组(放化疗组)33例。两组均采用常规放疗同期行PF方案化疗。观察组从放疗开始联合使用益气生血类中药直至放疗结束。比较两组病人在治疗期间肿瘤消退情况、血红蛋白改善情况、放疗急性反应等。结果:观察组的肿瘤缓解率(PR+CR)高于对照组分别为91.4%(32/35)和84.8%(28/33),但无统计学上的显著差异(P=0.471);观察组血红蛋白显著升高(P<0.001);观察组乏力发生率明显少于对照组(P<0.001)。结论:益气生血法对同步放化疗短期疗效无明显影响,但可减轻放化疗毒副反应,提高生活质量。

Objective： To investigate the efficacy and safety of Yiqi Shengxue Soup combined with concurrent chemoradiation in locally advanced nasopharyngeal cancer patients. Methods： Eligible patients with no prior chemoradiation were randomly assigned to receive concurrent chemoradiation（ regular radiation with DDP plus 5- FU） with or without Yiqi Shengxue Soup. The primary endpoint was objective response rate and secondary endpoint was the incidence of adverse events. Results： 68 patients,35 in concurrent chemoradiation with Yiqi Shengxue Soup group（ combination group） and 33 in concurrent chemoradiation alone group（ control group） were recruited. The objective response rate（ PR ＋ CR） was numerically but not statistically higher in combination group than in control group（ 91. 4% VS 84. 8%,P =0. 471）. The absolute value of hemoglobin at the end of treatment was significantly higher in combination group（ 110. 06 ± 6. 17 vs 90. 70 ± 5. 48,P〈0. 001）. The incidence of grade3 /4 fatigue was significantly lower in combination group（ 2. 9% vs 30. 3%,P〈0. 001）. Conclusion： Yiqi Shengxue Soup reduced the incidence of anemia and acute radiation effect of concurrent chemoradiation and improved the quality of life in locally advanced nasopharyngeal cancer patients.