摘要
A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.
A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.
基金
the National Natural Science Foundation of China (No. 21262020)
the Science and Technology Planning Project of Yunnan Province (No. KKSY201207140)
the Natural Science Foundation of Yunnan Education Department (No. 09Y0081)
the Analysis and Measurement Foundation of Kunming University of Science and Technology (No. 20130560) for their financial supports
