急性冠脉综合征患者血清半乳糖凝集素-3和C反应蛋白水平的变化

Changes of serum levels of Galectin-3 and C-reactive protein in patients with acute coronary syndrome

目的:观察急性冠脉综合征患者的血清半乳糖凝集素-3(Galectin-3)与C反应蛋白(CRP)的变化,并探讨其临床意义。方法:188例冠心病患者分为急性心肌梗死组(AMI组)52例、不稳定型心绞痛组(UAP组)76例、稳定型心绞痛组(SAP组)60例,另选同期59例健康者作为对照组。检测各组血清中Galectin-3和CRP的水平。结果:与对照组[(4.4±1.6)μg/L、(5.5±2.7)mg/L]和SAP组[(5.0±2.2)μg/L、(6.7±2.9)mg/L]相比,AMI组[(9.79±3.24)μg/L、(25.8±10.9)mg/L]和UAP组[(7.7±3.1)μg/L、(21.3±9.2)mg/L]血清Galectin-3、CRP水平均明显升高(F=12.439和16.649,P<0.001),且AMI组高于UAP组(P<0.05),对照组与SAP组之间差异无统计学意义(P>0.05)。结论:血清中Galectin-3和CRP与急性冠脉综合征临床事件的严重程度密切相关,可作为该类患者危险分层的参考指标。

Aim：To determine the serum levels of Galectin-3 and C-reactive protein（CRP） in patients with acute cor-onary syndrome（ACS）.Methods：A total of 188 patients with coronary heart disease （CHD） were enrolled in this study and 59 healthy persons were selected as control .Clinical phenotypes of CHD included acute myocardial infarction （ AMI） , unstable angina pectoris （ UAP） and stable angina pectoris （ SAP） .Serum levels of Galectin-3 and CRP were determined at 12 hours after the appearance of symptoms in AMI or on admission in other groups .Results： Compared with SAP group [（5.0 ±2.2） μg/L, （6.7 ±2.9） mg/L] and the control group[（4.4 ±1.6） μg/L, （5.5 ±2.7） mg/L], the levels of serum Galectin-3 and CRP were significantly higher in AMI group [（9.79 ±3.24） μg/L, （25.8 ±10.9） mg/L ]and UAP group[（7.7 ±3.1） μg/L, （21.3 ±9.2） mg/L]（F=12.439 and 16.649,P〈0.001）;the levels of Galectin-3 and CRP were significantly higher in AMI group than those in UAP group （P〈0.05）.There was no difference between SAP group and the control group（P〉0.05）.Conclusion：The serum levels of Galectin-3 and CRP are highly related to the severity of clinical events in patients with ACS , which might be used as reference markers for risk stratification in patients with ACS.