“毒瘾”复发的中医病理因素与生化指标的相关性研究

Study on Association between the TCM Pathological Factors and the Biochemical Indicators of “Addiction” Relapse

目的:探讨"毒瘾"复发的中医病理因素与相关生化指标之间的关联性。方法:对354例自愿参加调查的福州市强制戒毒所与福建省司法厅戒毒管理局所属强制戒毒所的自愿戒毒者,采集四诊信息,应用证素辨证方法提取中医病理因素,检测肝肾功能、血脂、血糖指标。结果:1)吸毒组在肝功、血脂方面均较健康组水平显著升高;肾功方面司法组较健康组水平下降;血糖方面公安组较健康组水平显著下降,司法组较健康组水平上升。2)公安组与司法组均病位上胆与肌酐显著相关,病性上阴虚与尿素氮显著相关。结论:吸毒者自身代谢状况与中医病理因素相关,相关生化指标可作为证素辨证的参考指标。

Objective：To explore the association between traditional Chinese medicine （ TCM） pathological factors and the biochemical indicators of “addiction” relapse of drug abusers .Methods：Three hundred and fifty four cases of drug addicts from compulsory detoxifi-cation institute of Fuzhou city and the jurisdiction of the Department of Justice of Fujian Province volunteered for the study .Information on four diagnostic methods was collected , and TCM pathological factors were extracted by using syndrome elements differentiation .Be-sides, liver and kidney function, blood lipids, blood glucose index were tested.Results：1）Levels of liver function and blood lipid of the drug addicts were significantly higher than those of the healthy group; level of kidney function of the judicial group was lower than that of the healthy group;level of blood glucose of the public security group were significantly lower than that of the healthy group , while the judicial group were higher than that of the healthy group .2） As for disease location , gallbladder was significantly related to CREA in both of the public security group and the judicial group; as for the nature of disease , Yin deficiency was significantly associated with BUN.Conclusion：Metabolism is relevant to TCM pathological factors in drug addicts during the rehabilitation period .Biochemical in-dicators can be taken as relevant evidence for syndrome elements differentiation .