麻芩咳喘合剂对哮喘慢性持续期呼出气一氧化氮水平的影响

Integrated Observation on FENO level of chronic persistent asthma with Maqin Kechuan mistura

目的观察麻芩咳喘合剂对哮喘慢性持续期患者呼出气一氧化氮水平的影响。方法支气管哮喘慢性持续期患者30例,随机分为治疗组14例,对照组16例。治疗组予以麻芩咳喘合剂口服,1剂/d,早晚温服;对照组吸入舒利迭(沙美特罗替卡松粉吸入剂)(50/250μg),1吸,2次/d,疗程1个月。观察治疗前后ACT评分、FENO、肺通气功能指标(包括FVC%、FEV1%、FEV1/FVC、PEF%)。采用IBM SPSS Statistics 19统计分析。结果治疗后2组患者症状均好转,ACT评分与疗前比较均具有统计学意义(P<0.001),组间比较无统计学意义;疗前2组患者呼出气一氧化氮水平升高明显,疗后均有明显下降,与疗前相比较具有统计学意义,疗后组间比较无统计学意义;2组患者肺通气功能均较治疗前好转,但组间及组内比较均无统计学意义。结论麻芩咳喘合剂治疗支气管哮喘慢性持续期能够改善患者症状,降低患者呼出气一氧化氮水平,控制气道炎症。

Objective To observe the effect of Maqin Kechuan Mixture treatment with reference to the FENO levels of continuous chronic asthma patients.Methods Collect 30 patients with continuous chronic bronchial asthma, among which 14 cases were randomly divided into the treatment group,the rest of the 16 cases the control group.Treatment group take Maqin Kechuan Mixture orally, 1 dose/d in each morning and evening when warm. The control group inhale Seretide （Salmeterol fluticasone propionate powder for inhalation）（50/250/xg） 1 dose per inhalation and twice/d,a course of treatment a month. Then observe the index of ACT score, FENO, and pulmonary ventilation before and after treatment （including FVC%, FEV1%, FEV1/FVC, PEF%） .IBM SPSS Statistics 19 statistical analysis has been used.Results After the treatment,both groups were improved. Compared with the index of patients before treatment, ACT score were of statistical significance （ P 〈 0. 001 ）. There was no difference between the two groups. The FENO levels of beth groups were significantly elevated before the treatment and were significantly reduced after the treatment. Compared with that before treatment,the FENO levels after treatment groups were of statistical significance. Comparison between groups after treatment showed no statistical significance. Compared with that before treatment, the lung ventilation functions of beth groups were improved after the treatment, while the comparison between groups and within the group showed no statistical difference. Conclusion Maqin Kechuan mixture could improve the condition of patients with chronic persistent asthma by reducing the FENO levels and improving the airway inflammation.