儿童百日咳样综合征病原临床分析

Pathogenic analysis of children pertussis-like syndrome

目的了解儿童百日咳样综合征的病原种类,为临床防治提供依据。方法选择年龄在3个月—8岁内有痉挛性咳嗽的患儿共554例。进行直接免疫荧光测定法检测呼吸道7种常见病毒：流感病毒A、B型（IFV A、IFV B）,腺病毒（ADV）,合胞病毒（RSV）,副流感病毒1、2、3型（PIV1、PIV2、PIV3）;并进行静脉取血,对肺炎支原体、衣原体抗体检测。结果 181例病原学检测为阳性,阳性率32.67%（181/554）。所检出的病原依次为RSV 77例（42.5%,77/181）,PIV3 60例（33.1%,60/181）,MP 32例（17.7%,32/181）,ADV 3例（1.7%,3/181）,IFVA 7例（3.9%,7/181）,混合感染3例（1.7%,3/181）,IFVB、PIV1和PIV2未检出。结论 3个月~3岁婴幼儿感染的病原主要为RSV和PIV3,3~8岁儿童检出的主要病原为肺炎支原体。

Objective To investigate the species of pathogenic children pertussis-like syndrome, and provide basis for clinical prevention and treatment. Methods Children with spastic cough at the age of 3 months to 8 years were selected. A total of 554 cases were given direct immunofluorescence assay for the detection of 7 kinds of common viruses of respiratory tract： IFV A,IFV B,ADV,RSV,PIV 1 ,PIV 2,PIV 3;and venous blood drawing for the detection of Mycoplasma pneumoniae and Chlamydia antibody. Result 181 cases had positive result in pathogenic test. The positive rate is 32.67% （181/554）. There were 77 cases of RSV（42.5% ,77/181） ,60 cases of PIV3（33.1% ,60/181） ,32 cases of MP（17.7% ,32/181） ,3 cases of ADV（1.7% ,3/181）,7 cases of IFVA（3.9% ,7/181） and 3 cases of mixed infection（1.7% ,3/181）. IFV B,PIV 1 and PIV 2 were not detected. Conclusion The main pathogens were mainly RSV and PIV 3 for 3 months to 3 years old infants, and the main pathogen is mycoplasma pneumoniae for 3 to 8 years old children.