疏肝和胃法对老年反流性食管炎患者生存质量的影响

Effects of liver-discharging and stomach-harmonizing therapy on quality of life in senile patients with reflux esophagitis

目的观察疏肝和胃法对老年反流性食管炎患者生存质量的影响，评价中医药治疗慢性疾病的疗效。方法选择2012年3月至2013年10月河南省中医院门诊和住院的反流性食管炎老年患者60例，按随机数字表法分为对照组与试验组，每组30例。对照组给予单纯西药治疗，试验组给予逍遥散加减联合奥美拉唑及吗丁啉治疗，治疗8周。用健康调查简易量表（SF-36量表）评价患者生存质量的改善程度，观察两组临床疗效及不良反应发生隋况。结果两组经治疗后，SF-36量表总评分、躯体健康评分（PCS）及精神健康评分（MCS）均明显升高，且以试验组升高程度更显著[量表总评分（分）：124．2±11．5比117．1±10．9，PCS（分）：67．9±5．3比62．9±6．2，MCS（分）：56．1±6．7比55．0±6．6，均P〈0．05]；试验组总有效率明显高于对照组（96．7％比80．0％，P〈0．05）。两组均未见明显不良反应发生。结论疏肝和胃法可改善老年反流性食管炎患者的生存质量。

Objective To observe the effeets ofliver-diseharging and stomaeh-harmonizing therapy on quality of life in senile patients with reflux esophagitis and to evaluate the therapeutic effect of traditional Chinese medicine （TCM） on chronic diseases. Methods Sixty patients with senile reflux esophagitis selected from in-patients and out-patients of Henan Province Hospital of TCM from Mareh 2012 to October 2013 were randomly divided into experimental group and eontrol group （eaeh, 30 patients） . The experimental group was treated with Xiaoyao powder （its ingredients eould be added or subtraeted according to the patient＇s individual situation） combined with omeprazole and domperidone, while in the control group, only western drugs, omeprazole and domperidone were applied. The therapies in both groups lasting for 8 weeks constituted one therapeutic course. The MOS 36-item short form healthy survey （SF-36） was used to evaluate the degree of improvement of patients, quality of life, and clinical effeets and adverse drug reaction were observed. Results The total scores of SF-36, physical and mental health scores of both groups were increased significantly, and the degree of elevation in scores in the experimental group was markedly higher than that in the eontrol group （total scores of SF-36 ： 124.2 ± 11.5 vs. 117.1 ± 10.9, physical health scores ： 67.9 ± 5.3 vs. 62.9 ± 6.2, mental health scores ： 56.1 ± 6.7 vs. 55.0 ± 6.6, all P〈 0.05 ）. The total effective rate of experimental group was mueh superior to that of eontrol group （ 96.7% vs. 80.0%, P〈 0.05 ） . No obvious adverse reactions happened in the two groups. Conclusion Liver-discharging and stomach-harmonizing therapy can improve the quality of life in aged patients with reflux esophagitis.