益智丹治疗儿童多动症的临床与实验研究

Clinical and Experimental Study on Treatment of Childhood Hyperkinetic Syndrome with Yizhidan

目的 :观察益智丹治疗儿童多动症 (CHS)的临床疗效及其作用机制。方法 :临床研究采用单盲法随机观察益智丹与利他林的临床疗效 ;实验研究制作记忆障碍模型 ,观察益智丹对小鼠学习记忆功能和对小鼠脑组织单胺类神经递质含量的影响。结果 :益智丹治疗CHS的显效率、总有效率分别为 4 5 56%、87 78% ,与利他林 ( 53 33%、86 67% )相当 ;Conners指数均明显降低 ,两组间疗效及多动指数比较差异均无显著性 (P >0 0 5)。益智丹还能显著改善患儿软神经征及异常脑电图 ,副反应明显低于利他林组 (P <0 0 1)。对东莨菪碱、亚硝酸钠、乙醇所致的小鼠学习记忆障碍有明显的改善作用 (P <0 0 5) ;且能够显著提高小鼠脑组织多巴胺 (DA)含量 ,与对照组比较差异有显著性 (P <0 0 1) ;对二羟苯乙酸 (DOPAC)、去甲肾上腺素 (NE)、3 甲氧 4 羟基苯乙酸 (HVA)、5 羟色胺 ( 5 HT)、5 羟吲哚乙酸 ( 5 HIAA)也有不同程度的影响。结论 :益智丹是治疗CHS的有效药物 ,其作用机制可能与改善记忆、提高脑组织DA含量有关。

To observe the clinical effect of Yizhidan (YZD) in treating childhood hyperkinetic syndrome (CHS) and its mechanism. Methods: Random single blind method was used in clinical study to observe the clinical effect of YZD and compared with that of Ritalin. The dysmnesia model animal was used to observe the effect of YZD on learning memory function and cerebral monoamine neurotransmitter content. Results: The markedly effective rate and the total effective rate of YZD were 45.56% and 87.78%, which were similar to those of Ritalin (53.33% and 86.67%). The Conners index lowered in both groups, showing insignificant difference (P>0 05). Experimental observation showed that YZD could significantly improve the soft neurologic signs and abnormal encephalogram with less side-effects in comparing with Ritalin (P<0 05). Moreover, YZD could obviously improve the learning memory disturbance induced by scopolamine, sodium nitrite and ethanol, and significantly increased the contents of DA in cerebral tissue, as compared with that of the control group, the difference was significant (P<0 01). It also showed effect on DOPAC, NE, HVA, 5-HT and 5-HIAA of mice in certain degree. Conclusion: YZD is an effective drug in treating CHS, its mechanism might be probably related to the improvement of the memory and the enhancement of DA receptor in cerebral tissue.