^(103)Pd同位素支架预防支架内再狭窄的实验研究

Preventive role of ^( 103)Pd-radiative stent on in stent restenosis in rabbits

目的 探讨10 3 Pd同位素支架对支架植入术后再狭窄的预防作用。方法 对雄性新西兰白兔 5 0只进行腹主动脉球囊拉伤后 ,分别置入10 3 Pd同位素支架 (同位素支架组 )和普通支架 (普通支架组 )各 2 5只。两组分别于术后 3d和 1、2、4、8周分批进行血管病理形态学、免疫组织化学测定和血管造影检查。结果 血管拉伤后 8周 ,血管造影显示 ,同位素支架组血管最小内径显著大于普通支架组 (P <0 .0 5 ) ;血管狭窄程度明显减低 (P <0 .0 5 ) ;病理形态学和免疫化学染色分析表明 ,两组血管损伤程度相同。受同位素辐射作用后 ,血管内膜增生受到显著抑制 ,管腔狭窄程度减轻。结论10 3 Pd同位素支架在动物实验中具有明显预防支架内血管再狭窄的作用。

Objective To investigate the preventive role of 103 Pd radiative stent on in stent restenosis in rabbits. Methods Fifty male New Zealand white rabbits were divided into two groups: control group (balloon injury followed by stent implantation, n =25) and treatment group (balloon injury plus 103 Pd radiative stent implantation, n =25). At the end of 3 day, 1 week, 2 week, 4 week and 8 week after injury, the animals of the treatment group underwent arterial angiography. All animals in both groups were killed for histomorphometrical and immunohistochemical studies on abdominal arteries. Results Compared with the control group, the inner diameter was greater ( P <0.05) in the 8 week subgroup; the rate of neointimal proliferation and vascular stenosis in rabbits received 103 Pd radiative stent were suppressed and no radioactivity was detected in peripheral blood. Conclusion 103 Pd radiative stent could prevent in stent restenosis significantly in rabbits.