肝肿瘤化学灭活治疗的初步报告

Preliminary report of the chemo ablation of hepatic neoplasms.

目的 :了解小肝癌和肝转移癌行经皮乙酸注射 (简称PAI)的临床效果。方法 :5例小肝癌、3例肝转移癌在CT引导下经皮乙酸注射化学灭活术。结果 :在 8例中 ,除 3例在注射时有明显腹痛外 ,没有其他的临床并发症。随访 2～ 7个月 ,7例病人的肿瘤病变成为低密度至囊状改变 ,1例于PAI后 1周行部分肝切除术 ,病检示肿瘤全部坏死。结论 :初步结果表明 ,在小肝癌和 1至 3个小病灶的肝转移癌中PAI是有效的 。

Objective:To assess the clinical efficacy of CT guided percutaneous acetic acid injection(PAI) for chemo ablation of hepatic neoplasms.Methods:5 small hepatocellular carcinomas(HCCs) and 3 hepatic metastatic carcinomas(HMCs) were performed chemo ablation of PAI under the CT guidance.Results:Results of the preliminary study of PAI showed that no clinically significant complications occurred except remarkable abdominal pain in 3 of 8 PAIs.7 lesions became less dense to cystic after2～7months of CT follow up.One patient was performed surgical partial hepatic resection,there was no neoplastic cell in the lesion unless a complete necrosis of tumor.Conclusion:The initial results of PAI suggest that chemo ablation of small HCCs and small 1～3 foci of HMCs may prove to be an effective method.It is promising that PAI will take the place of partial hepatic resection for treatment of small HCCs and other hepatic neoplasms.