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乳腺癌中乙醛脱氢酶1与上皮性钙黏蛋白、神经性钙黏蛋白关系的研究 被引量：3

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摘要 乳腺癌干细胞是一类具有自我更新及多向分化潜能的原始细胞，在一定条件下可以分化成多种不同功能的细胞，从而影响乳腺癌的发生、发展、转移、耐药及复发等生物学行为[1]。上皮-间质转化（epithelial-mesenchymal transition， EMT）在乳腺癌浸润转移过程中起着重要作用。本实验应用免疫组织化学方法研究乳腺癌干细胞标志物乙醛脱氢酶1（ALDH1）蛋白与 EMT 标志蛋白上皮性钙黏蛋白（E-cadherin）、神经性钙黏蛋白（N-cadherin）在正常乳腺组织、乳腺癌、转移性淋巴组织中的表达情况，探讨乳腺癌干细胞与乳腺癌浸润转移的关系。
作者 蔡建英 吴诚义
机构地区 重庆医科大学附属第一医院内分泌乳腺外科
出处 《中国医药生物技术》 2014年第3期231-233,共3页 Chinese Medicinal Biotechnology
关键词 上皮性钙黏蛋白 乳腺癌干细胞 乙醛脱氢酶 神经性 E-cadherin N-CADHERIN 免疫组织化学方法 多向分化潜能
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献12

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二级参考文献23

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共引文献37

同被引文献36

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引证文献3

二级引证文献9

中国医药生物技术
2014年 第3期

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