抗感染治疗对乙型肝炎肝硬化并自发性细菌性腹膜炎的影响及分析

Affect and analysis of anti-infection treatment for patients with HBV-related liver cirrhosis complicated with spontenous bacterial peritonitis

目的探讨抗感染治疗对乙型肝炎肝硬化并自发性细菌性腹膜炎(SBP)患者血清降钙素原(PCT)和血清C-反应蛋白(CRP)水平的影响。方法对本院2012年1月至2013年2月所收治的98例乙型肝炎肝硬化患者的临床资料进行回顾性分析。结果乙型肝炎肝硬化患者血清PCT和CRP水平均显著高于对照组,且感染组血清PCT、CRP水平显著高于无感染组(F=4.419、5.807,P<0.05);感染组患者治疗后血清CRP、PCT水平显著下降(t=6.428、3.513,P<0.05);且经Spearman相关分析,患者血清CRP和PCT水平与SBP的严重程度具有良好的正相关性。结论血清PCT和CRP水平是诊断乙型肝炎肝硬化并SBP的重要指标,抗感染治疗可显著降低PCT和CRP的水平。

Objective To investigate the influence of anti-infection treatment on levels of serum procalcitonin （PCT） and serum C-reactive protein （CRP） in patients with HBV-related liver cirrhosis complicated with spontaneous bacterial peritonitis （SBP）. Methods The clinical data of 98 patients with HBV-related liver cirrhosis in our hospital from January 2012 to February 2013 were analyzed, retrospectively. Results The levels of serum PCT and CRP of patients with HBV-related liver cirrhosis were signiifcantly higher than those in control group. The levels of serum PCT and CRP of patients in infection group were signiifcantly higher than those without infection （F=4.419, 5.807;P〈0.05）. After treatment, the levels of serum PCT and CRP in patients with infection were decreased signiifcantly （t=6.428, 3.513;P〈0.05）. While by the Spearman correlation analysis, the levels of serum CRP and PCT and the severity of the SBP had good positive correlations. Conclusions The levels of serum PCT and CRP are important indicators for diagnosis of HBV-related liver cirrhosis complicated with SBP. Anti-infection treatment could signiifcantly reduce the levels of PCT and CRP.