205例丙型肝炎患者血脂水平的检测与分析

Detection and analysis of lipids on 205 patients with hepatitis C

目的探讨分析维吾尔族和汉族丙型肝炎患者血脂水平的变化及临床意义。方法对205例丙型肝炎患者外周血采用酶联免疫吸附法检测抗-HCV、荧光定量聚合酶链反应法检测HCV RNA,均相酶比色法检测高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(Tch)和甘油三酯(TG)。采用免疫比浊法检测脂蛋白(a)[LP(a)]、载脂蛋白A1(apoA1)、载脂蛋白B(apoB)的水平,并进行统计分析。结果维吾尔族丙型肝炎患者HCV RNA的阳性率为79.46%,显著高于汉族患者(65.59%),维吾尔族丙型肝炎患者HDL-C、Tch和apoA1的含量分别为(1.78±0.96)mmol/L、(3.38±1.79)mmol/L和(1.59±0.83)g/L,显著低于汉族患者[HDL-C、Tch和apoA1的含量分别为(2.25±1.29)mmol/L、(4.37±1.34)mmol/L和(1.95±0.88)g/L],差异均具有统计学意义(P均<0.05),但两民族患者间的抗-HCV阳性率、LDL-C、TG、LP(a)和apoB比较,差异无统计学意义(P>0.05)。结论与汉族丙型肝炎患者相比,维吾尔族丙型肝炎患者HCV RNA的阳性率高,而Tch、HDL-C和apoA1的含量降低,提示维吾尔族丙型肝炎患者肝细胞受损可能更为严重。

Objective To explore the changes and clinical signiifcance of lipids of Uygur and Han patients with hepatitis C. Methods Total of 205 cases with hepatitis C were collected. The serum levels of antibody of HCV of the 205 patients were detected by enzyme-linked immunosorbent assay. HCV RNA were detected by fluorescence quantitative polymerase chain reaction. Homogeneous enzyme assay was used to detect high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, total cholesterol （Tch） and triglycerides （TG）. Turbidimetric immunoassay was used to detect lipoprotein（a） [LP（a）], apolipoprotein A （apoA1） and apolipoprotein B （apoB）, then statistically analysis the data were done, respectively. Results The positive rate of HCV RNA were signiifcantly higher in Uygur （79.46%） than Han patients （65.59%）, the rates of HDL-C, Tch and apoA1 were signiifcantly lower in Uygur patients [（1.78 ± 0.96） mmol/L, （3.38 ± 1.79） mmol/L and （1.59 ± 0.83） g/L, respectively] than that in Han patients [ （2.25 ± 1.29）, （4.37 ± 1.34） and （1.95 ± 0.88） g/L, respectively], with signiifcant differences （P all〈0.05）. For the positive rate of antibody of HCV, LDL-C, TG, Lp （a） and apoB, there were no signiifcant difference between Uygur and Han patients （P〉0.05）. Conclusions The positive rate of HCV RNA were signiifcantly higher for Uygur patients with hepatitis C than Han patients, while the content of HDL-C, Tch, and apoA1 were lower, it suggested degree of damage in the liver cells of Uygur patients with hepatitis C might be more serious.