影响舌鳞状细胞癌预后的临床病理因素分析

Clinical pathology as prognostic factors in squamous cell carcinoma of tongue

目的 研究影响舌鳞状细胞癌预后的临床病理因素。方法 以TNM分类、病理分级、淋巴细胞浸润程度、浸润厚度、病理核分裂数、微血管数等指标来研究与舌鳞状细胞癌预后有关的因素。结果 分化程度、淋巴细胞浸润程度、浸润厚度、微血管数、病理核分裂数与区域淋巴结转移无关 ;肿瘤大小与区域淋巴结转移有关。肿瘤大小、淋巴细胞浸润程度、微血管数等指标与术后复发转移无关 ;浸润厚度、分化程度、病理核分裂数与术后复发转移有关。结论 对于肿瘤直径大的舌鳞状细胞癌应积极采取颈淋巴结清扫术 ;分化程度低者易出现术后复发转移 ;舌鳞状细胞癌浸润厚度超过 6mm时、病理核分裂数大于 2个 /每高倍镜视野时 。

Objective To study clinical pathology prognostic factors in squamous cell carcinoma of tongue.Methods26 squamous cell carcinoma of tongue were analyzed by means of several clinical and pathology factors.Results Differentiation,invasion degree of lymph cell,tumor thickness,the number of capillary and pathological karyokinesis were not related with cervical lymph node spreading.Tumor size was the related factor.And,tumor size,invasion degree of lymph cell and the number of capillary were not related with prognosis.Tumor thickness,differentiation and the number of pathological karyodinesis were the related factors.Conclusion We should perform neck dissection when tumor size is large.It is easy to recur and metastases when the tumor is poorly differentiated,tumor thickness is greater than 6mm and the number of pathological karyokinesis is more than two.