缬沙坦降压、逆转肾性高血压大鼠左室肥厚和对血小板聚集率的影响

The Effects of Valsartan on Systolic Blood Pressure, Left Ventricular Hypertrophy and Blood Platelet Aggregation in Renovascular Hypertensive Rats

目的 :观察血管紧张素 的 1型 (AT1 )受体拮抗剂缬沙坦与血管紧张素转换酶抑制剂依那普利对肾性高血压左室肥厚大鼠血压、心肌重量及对血小板聚集率的影响。方法 :建立两肾一夹 (Goldblott)肾性高血压大鼠致左室肥厚模型。大鼠左室肥厚形成后 ,缬沙坦与依那普利灌胃给药连续 12周 ,观察两药对大鼠血压、心肌重量和血小板聚集率的影响。结果 :大鼠左侧肾动脉部分钳夹后 ,其收缩压、左心室湿重与体重的比值及血小板聚集率均高于正常对照组。在大鼠左室肥厚形成后 ,缬沙坦与依那普利连续给药 12周 ,可显著降低收缩压、左心室湿重与体重的比值 ,抑制血小板聚集率。结论 :肾性高血压大鼠左室肥厚形成后 ,缬沙坦与依那普利长期给药 ,具有降压。

Objective:To investigate the effects of Valsartan (a sort of nonheterocyclic angiotensin Ⅱ antagonist) and Enalapril on systolic blo od pressure(SBP), left ventricular hypertrophy(LVH) and blood platelet aggregati on in renovascular hypertension rats(RHR).Methods:Establish the mode l of RHR with LVH by clipping the left renal artery (two kidneys, one clip model ). Eight weeks later,Valsartan and Enalapril were given by perfusing stomach to rats daily for twelve weeks to examine the affects on SBP, LVH and blood platele t aggregation. Results: After twenty weeks of clippling of the left renal artery,the SBP,the ratio of left ventricar wet weight/body weight(LVWW/BW) and blood platelet aggregation were more increased than those in the control gro up. Twelve weeks treatment of valsartan and Enalapril can decrease SBP, LVWW/BW and blood platelet aggregation on RHR with LVH.Conclusion:Both Valsartan and Enalapril have regressive effects and ca n decrease blood pressure and blood platelet aggregation.