平均红细胞体积和红细胞体积分布宽度临床意义的分析

Clinical Analysis of the Mean Corpuscular Volume and Red Cell Volume Distribution Width

目的 :建立一种有效实用的方法 ,对难治性贫血 (RA)和慢性再生障碍性贫血 (CAA)进行早期鉴别诊断。方法 :采用回顾性分析的方法 ,运用 Hemacell Plus全自动血细胞计数分析仪检测 2 3例 RA组和 2 2例 CAA组以及 40例正常对照组的血常规 (血RT) 18项 ,并对其中的平均红细胞体积 (MCV)、红细胞体积分布宽度 (RDW)两项指标进行均数比较及配对 t检验。结果 :RA组MCV为 (113.80± 7.16 ) f L、RDW为 (2 3.15± 6 .41) % ,均显著高于正常对照组 [(89.0 9± 2 .13) f L,P<0 .0 0 1、(12 .6 9± 1.34 ) % ,P<0 .0 0 1];而 CAA组的 MCV为 (93.17± 6 .2 3) f L ,RDW(x± s)为 (17.97± 2 .13) % ,虽高于正常人 ,但前者差异无显著性 (P>0 .0 5 ) ,而后者差异有显著性 (P<0 .0 0 1)。结论 :MCV和 RDW的检测简便、快捷、准确 ,可作为 RA和 CAA的早期鉴别诊断的定量指标 ,并为临床治疗。

Objective:To establish an effective method for the ea rly differential diagnosis of refractory anemia (RA) and chronic aplastic anemi a (CAA), and the difference of these two diseases. Method:A total of 8 5 cases of full (23 RA?22 CAA?40 controls) were retrospectively analyzed. Mean corpuscular volume (MCV) and red cell volume distribution width (RDW) were meas ured in 45 patients (23 RA and 22 CAA) and 40 controls by Hemacell plus blood ce ll meter. Results:MCV? RDW were (113.80±7.16) fL (x±s )?(23.15±6.41)% (x±s) in patients with RA, which were also sign ificantly higher than that in the controls [(88.09±2.13) fL (x[TX-]±s ), P<0.001? (12.68±1.31)% (x±s),P<0.001]; MCV?RDW we re (93.13±6.23) fL (x; MCV?RDW we re (93.13±6.23) fL (x±s)?(17.96±2.13)% (x±s) in p atients with CAA, The former was not significantly higher than that in the contr ols, P>0.05,but the latter was,P<0.001.Conclusion:The resu lts showed that it was an easy, rapid and precise method for the detection of MC V and RDW highly recommended. It is reatment, monitor of RA and CAA.