血清CA_(125)在诊治子宫内膜异位症中的评价

Evaluation of serum CA_(125) in diagnosis and treatment of patients with endometriosis

目的探讨血清CA12 5对诊治子宫内膜异位症 (endometriosis,EMT)的临床价值。方法采集空腹血清 47份 ,分研究组 (EMT) ,术前 2 0例 ,术后 5例 ,正常对照组 7例 ,疾病对照 (盆腔炎 7例 ,卵巢肿瘤 8例 ) ,用药盒测定各组血清CA12 5值。结果EMT治疗前后血清CA12 5值差异有显著意义 ,P<0 0 5 (t=2 19)。EMT与正常对照比P <0 0 0 1,与疾病对照组比 ,P <0 0 2及P <0 0 5 ,均有明显差异 ,EMT血清CA12 5水平与疾病严重程度呈正相关 ,P <0 0 2 (γ =0 6 9)。结论血清CA12 5测定在EMT诊断中有一定价值 ,但因特异性不高 ,应结合B超、CT、MRI等手段以增加诊断可靠性 ,然而监测CA12 5水平在判断EMS的临床分期 ,疾病转归及评估治疗效果方面较诊断EMT更有价值。

Objective To explore the clinical value of serum CA 125 in diagnosis of patients with endometriosis (EMT). Methods Fasting sera ( n =47) were collected and were divided into EMT ( n =25, 20 cases of preoperative patients and 5 cases of postoperative patients), normal control ( n =7) and disease control ( n =15, 7 cases of pelvic inflamatory disease and 8 cases of ovarian tumors). The CA 125 in sera from each group was determined by test kit. Results The value of serum CA 125 in EMT group was significantly different from that in normal control and disease control. Within EMT group, serum CA 125 in preoperative cases has significant difference from that in postoperative cases, and was related to the stages of disease( P <0.05, r =0.69). Conclusions There was definitive value in diagnosis of EMT by determing serum CA 125 , but with low specificity. This method should combine with other detective means such as B ultrasound, CT, MRI, etc., to improve the reliability of diagnosis. By monitoring serum CA 125 , to evaluated the clinical stages, prognosis and treating effect of EMT is more valuable than to diagnose it.