腺苷对兔缺血-再灌注心肌的保护作用

Effect of adenosine on ischemic myocardial at different stages of ischemic reperfusion

目的研究腺苷对兔缺血 再灌注心肌的梗死范围和心肌收缩功能的影响。方法采用在体兔心肌缺血再灌注模型 ,用RM 6 2 80多道生理记录和分析处理系统监测心肌收缩功能指标 ,Evans蓝 TTC法测量心肌梗塞范围 ,缺血再灌注前及后即刻给腺苷两组与对照组作对比分析。结果与对照组比较 ,腺苷预处理组心肌梗死范围明显减少 (P <0 0 1) ;左室内压峰值 (LVSP)恢复率和 +dp/dtmax恢复率明显增高 (P <0 0 5 ) ;心律失常发生率降低 ;而缺血 /再灌注即刻给予腺苷 ,以上指标差异均无显著意义。结论缺血前给予腺苷对再灌注心脏具有保护作用 ,可改善缺血 再灌注收缩功能 ,缩小心肌梗塞范围 ,减少再灌注心律失常发生率。

Objective To investigate the effects of adenosine on ischemic myocardial at per ischemia and pos ischemia. Methods Using rabbit ischemic reperfusion model, the contractile function and infarct size of rabbit hearts were determined by RM 6280 Multichannel Recording System and dual staining with TTC-Evan's blue dye. Results Compared with the control group, the infarct sizes were significantly reduced ( P <0.01), left ventricular systolic pressure (LVSP) and +dp/dt max were better restored ( P <0.05) and the occurrence of arrhythmia was lower in the rabbits treated by adenosine at pre ischemia. No effects was found in the rabbits treated by adenosine at post ischemia. Conclusion Adenosine can improve the contractile function and diminish the myocardial infarct size of the heart undergoing ischemia when it was used before ischemia.