40例原发性鼻腔非霍奇金淋巴瘤疗效分析

Analysis of Therapeutic Efficiency in Forty Patients with Primary Nasal Non-Hodgkin Lymphoma

目的对 40例原发性鼻腔非霍奇金淋巴瘤 (PNNHL)进行回顾性分析 ,以探讨其最佳治疗选择及其预后有关的因素。方法将 40例患者分为单纯放疗 ,单纯化疗及综合治疗三组 ,对其 1、3、5年生存率作相关比较。生存率用寿命表法统计 ,并作多因素卡方检验。结果通过 5年生存率 (SR5)比较结果表明 ,单纯放疗及综合治疗优于单纯化疗 ,临床Ⅰ、Ⅱ期的疗效优于Ⅲ、Ⅳ期。结论放射治疗是PNNHL治疗的最佳选择。临床分期早且无消瘦、发热、盗汗症状及采用放疗为主治疗是预后好的主要因素。

Objective A retrospective analysis of forty cases with primary nasal non-Hodgkin lymphoma(PNNHL) was performed to investigate its optimal choice of treatment and prognosis-related factors.MethodsForty cases were divided into three groups--(1)Treated with radiotherapy alone;(2)treated with chemotherapy alone;and (3)treated by combined therapy. The clinical effects of three groups were compared each other using 1,3 and 5 year-survival rates. The survival rate was statistically calculated by lifetable and multiple factor log-rank test. Results Having compared with the five-year survival rates(SR5),the therapeutic efficacy in first and third groups was better than that in second group; whereas that of patients in stage Ⅰ and Ⅱ was better than those in stage Ⅲ and Ⅳ. Conclusions The optimum choice of treatment for PNNHL is radiotherapy. The main favorite factors of prognosis could be the earlier clinical stage; without symptoms of emaciation, fever and night sweating; as well as adopting radiotherapy as the major measure of treatment.