高胆汁酸血症对肝脏能量代谢的影响

The effects of high serum concentration of bile acids on the energy metabolism of liver

目的 探讨高胆汁酸血症单一因素对肝脏能量代谢的影响。方法 经Wistar大鼠颈内静脉持续给予外源性胆汁酸 ,升高其外周血清中胆汁酸浓度 ,模拟阻塞性黄疸患者外周血清中胆汁酸的变化规律 ,观察腹腔动脉血酮体比值及肝组织能荷变化 ,时间一周。结果 随外周血清中胆汁酸浓度的升高 ,腹腔动脉血酮体比值、肝组织能荷均呈进行性下降。结论 高胆汁酸血症时肝脏能量代谢受损 ,表明在阻塞性黄疸患者肝功能损害中高胆汁酸血症起了重要作用。

Objective To explore the effect of high serum concentration of bile acids on energy metabolism of liver.Methods Bile acids were continously infused into the Wistar rats to simulate the serum concentration change of patients with obsturctive jaundice.Serum bile acids concentration,arterial blood ketone body ratio and energy charge of liver were determined.Results Aterial blood ketone body ratio and energy charge of liver decreased with the increase of serum bile acids concentration.Conclusion High serum concentration of bile acids plays an important role in hepatic fumction injury caused by biliary obstruction.