紫外线照射对银屑病患者淋巴细胞CD_(44)及CD_(54)分子表达的影响

The Effects of Ultraviolet Rays on the Expression of CD_(44) and CD_(54) in Psoriatic Patients

目的 进一步了解紫外线照射 (UVR)对银屑病患者系统免疫的影响。方法 采用流式细胞仪对UVR治疗前后银屑病患者淋巴细胞CD4 4及CD54 的表达进行研究。结果 ①银屑病患者CD4 4及CD54 表达量较对照组显著增高 (P均 <0 .0 0 1) ;②UVR治疗后患者CD4 4及CD54 表达量显著降低 (P <0 .0 0 1,P <0 .0 5 ) ;③停止治疗半月后 ,患者CD4 4及CD54 表达量接近治疗前水平。结论 UVR治疗银屑病可能与其减少淋巴细胞粘附分子表达有关。

Objective In order to further understand the effects of UVR on immune system of psoriatic patients.Methods By using flow cytometry,we studied the expression of CD 44 and CD 54 of lymphocytes from psoriatic patients before and after UVR therapy.Results ①Compared with normal subjects,increased expression of CD 44 and CD 54 of lymphocytes in psoriatic patients was observed( P <0.01);②Decreasecl expression of CD 44 and CD 54 in psoriatic patients was observed after UVR therapy( P <0.001, P <0.05);③Expression of CD 44 and CD 54 approached the level before UVR therapy when the therapy stopped half month later.Conclusion The results indicate that UVR therapy for psoriasis may be correlated with the decreased expression of lymphocyte adhesion molecules.