左旋氧氟沙星治疗单纯性淋病合并衣原体和/或支原体感染的临床观察

Clinical Comparing Study of the Tfficacy of the Treatment of Uncomplicated Gonorrhea Co-infected Chlamydia trachomatis and Mycoplasma by Levofloxacin or Cetriaxone Pulse Doxycycline

目的 比较两种治疗方案 (左旋氧氟沙星 2 0 0mg 2次 /d共 7天与头孢三嗪 2 5 0mg单剂量肌注加强力霉素 10 0mg 2次 /d共 7天 )治疗单纯性淋病合并衣原体和 /或支原体感染各 3 0例的有效性和安全性。 方法 采用随机、开放、对照研究 ,试验组及对照组各 3 0例。结果 两组病例的痊愈率分别为 83 .3 3 %和 86.67% ,总有效率为 90 %和 93 .3 3 % ,差异无显著性 (P >0 .0 5 ) ;副反应发生率分别为 3 .3 3 %和 16.67% ,差异有显著性 (P <0 .0 5 )。结论 口服左旋氧氟沙星方案可作为治疗淋病合并衣原体和 /或支原体感染的治疗方法之一。

Objective To compare the efficacy and safety of two regimens in the treatment of uncomplicated gonorrhae co infected with chlamydia/mycoplsma.Methods A randomized,open,and parallel control clinical trial.Group A was treated with Levofloxacin 200mg,two times daily for 7 days;Group B was treated with Ceftriaxone 250mg,intramascularly for single dose plus Doxycline 100mg,two times daily for 7days.Results Each group had 30 patients,the efficacy rate for group A and group B was 90% and 93.3% respectively,no significant difference was found between two groups( P >0.05);the occurring rate of adverse effects was 3.33% and 16.67% respectively,a significant difference existed between the two groups(P<0.05).Conclusion Levofloxacin can be used in treatment for uncomplicated gonorrhae co infected with chlamydia/mycoplsma effectively and safety.