止痛灵贴剂治疗小儿痉挛性肠绞痛临床与实验研究

Treatment of Infantile Spastic Intestinal Colic with Zhitongling Plaster

目的 探讨止痛灵贴剂外敷治疗小儿肠绞痛的临床疗效及对实验小鼠镇痛作用的机理。方法 将 1 4 6例痉挛性肠绞痛患儿随机分为 2组 ,分别外敷止痛灵贴剂及暖脐膏 ,观察临床疗效 ,并记录治疗前后病情变化 ,按其腹痛程度 (轻、中、重 )采取记分方法评价 ;对实验小鼠进行给药前后痛阈观察。结果 观察组总有效率 ( 86.73 % )明显高于对照组( 62 .5% ) ,2组比较有显著差异 (P <0 .0 1 ) ;止痛灵贴剂能提高小鼠痛阈 ,有良好的镇痛效果。结论 止痛灵贴剂治疗小儿痉挛性肠绞痛疗效显著。止痛灵贴剂能提高小鼠痛阈。

OBJECTIVE To investigate into the effect of Zhitongling Plaster in the treatment of infantile spastic intestinal colic and its analgesic effect on experimental mice. METHOD 146 children with spastic intestinal colic were divided randomly into two groups, using Zhitongling Plaster and Luanqi Plaster respectively. RESULT The total effective rate in the observation group (86.73%) was markedly higher than that in the control group (62.5%), with significant difference (P<0.01). Zhitongling Plaster could increase the pain threshold of mice with satisfactory analgesic effect. CONCLUSION Zhitongling Plaster has marked therapeutic effect for infantile spastic intestinal colic and can increase the pain threshold of mice.