不同时辰给药对哮喘豚鼠血浆内皮素的影响

Effect of Drug Administration at Different Time on Plasma Endothelin of Guinea Pig with Asthma

目的 观察不同时辰给药对哮喘豚鼠血浆内皮素的影响。方法 将健康豚鼠 50只造成哮喘模型 ,根据中医阴阳理论以及哮喘发病的特点 ,随机分为 5组 ,对哮喘豚鼠进行了按时辰给药治疗的方法 ,观察各组豚鼠血浆内皮素的变化。结果 经统计学处理晚 2 1时 1次给药全量组和半量组治疗效果较每日 2次给药组和晨 9时 1次给药组好 ,P <0 .0 1。结论 应用中医阴阳理论 ,按时辰给药可以达到较小给药剂量 ,获得较为满意的疗效。

OBJECTIVE To observe the effect of drug administration at different time on the plasma endothelin of guinea pig with asthma. METHOD Asthma models were made with 50 healthy guinea pigs and the models were randomly divided into three groups. RESULT Statistics shows that giving full or half dosage of drug once a day at 21 o′clock can obtain better result than giving drug twice a day or once at 9 o′clock in the morning. CONCLUSION Giving drug at the appropriate time according to the theory of yin and yang can achieve satisfactory therapeutic effect.