窒息新生儿NAG及GGT的改变及临床意义

CHANGE OF N-ACETYL-β-D-GLUCOSAMINIDASE AND γ-GLUTAMYL TRANSPEPTIDASE IN POSTASPHYXIAL NEWBORNS AND IT'S CLINICAL SIGNIFICANCE

目的 :比较尿中N -乙酰 - β氨基酸葡萄糖苷酶 (NAG)、γ -氨酰转移酶 (GGT)及血清尿素氮 (BUN)、肌苷 (Cr)等指标在窒息新生儿肾功能损伤的早期诊断中的作用。方法 :测定对照组、轻度窒息组和重度窒息组新生儿的血清中BUN、Cr、尿中NAG和GGT。结果 :发现血清BUN、Cr各组间比较差异无显著性 (P >0 .0 5 ) ;尿中NAG及GGT轻度窒息组高于对照组 ,差异具显著性 (P <0 .0 5 ) ;重度窒息组较轻度窒息组和对照组明显升高 ,差异具显著性 (P <0 .0 5 )。结论 :提示尿中NAG、GGT活性是对窒息新生儿肾损伤的早期诊断及损伤程度的判定的一个灵敏指标。

Objective: To investigate the role of urinary N-acety1-β -D- glucosaminidase(NAG) and γ -glutamyl transpeptidase(GGT), and serum BUN and Cr in early detecting renal injury in postasphyxial newborns. Methods: 28 newborns with asphyxia were divided into mild asphyxia group (10 cases) and serious asphyxia group (18 cases), 9 normal newborns were regarded as control. The activities of NAG and GGT in urine, and BUN and Cr in serum were detected in 24 hour.Results: There were no significant differences in serum BUN and Cr between control and mild asphyxia groups and between the two asphyxia groups. But, the urinary enzymes (NAG, GGT) in serious group were higher than those in both mild asphyxia group and control(P<0.05), and compared with control, the urinary enzymes of mild asphyxia group were also significantly increased (P<0.05). Conclusion: These findings indicated that the activity of urinary enzyme in an early sensitive indicator, which may be used to detect the renal injury and it's severity in postasphyxial newborns.