四抗神农养生片对实验性胃溃疡的抑制作用

INHIBITION EFFECTS OF SI KANG SHEN NONG YANG SHENG PIAN TABLET ON EXPERIMENTAL GASTRIC ULCERS

目的 :通过动物实验观察四抗神农养生片的抗胃溃疡作用。方法 :选用盐酸、消炎痛加乙醇、乙酸制备胃溃疡模型 ,观察试药对实验性胃溃疡的作用 ;采用Mett毛细玻管法、试管倍比稀释法等观察、测定试药对胃肠功能的作用及MIC(最低抑菌浓度 )和MGC(最低杀菌浓度 )。结果 :试药组与对照组比较 ,盐酸、消炎痛加乙醇、乙酸 (术后 1 0天 )所致溃疡的溃疡指数分别由 99.6 8± 2 0 .93降为 38.47± 1 8.92、43.6 8± 1 2 .93降为 2 6 .47± 6 .92、1 8.99± 2 .49降为 7.1 3± 1 .32 (均为p <0 .0 1 ) ;胃蛋白酶活性由 5 43.6 8± 6 2 .93u降为 2 5 6 .87± 2 9.42u(p <0 .0 1 ) ;胃酸pH值由 2 .70± 1 .1 9升到 4.32± 1 .5 8(p <0 .0 5 )。MIC和MGC分别为 3.1 %、6 .3% ;抑菌强度为 + +。结论 :四抗神农养生片具有明显的抗胃溃疡作用。

Objective: To observe the anti-gastric ulcer effects of Si Kang Shen Nong Yang Sheng Pian tablet by animal experiment. Methods: The effects of test drug were observed on experimental gastric ulcer models which were produced by HCl, indomethacin plus ethanol, or acetic acid, the influence of test drug on function of stomach and intestine was observed and MIC and MGC of test drug were measured by means of Mett glass capillaries method and proportional dilution method in the test tabes and so on. Results: Gastric ulcer indexes of ulcers caused by HCl, indomethacin plus ethanol, and acetic acid (10 days after operation) decreased from 99.68±20.39 to 32.47±18.92, from 43.68±12.93 to 26.47±6.92 and from 18.99±2.41 to 7.13±1.82, 10(P<0.01) respectively. Pepsin activeness reduced from 543.68±62.93u to 56.87±29.42u (P<0.01), gastric acid pH increased from 2.70±1.19 to 4.32±1.58(P<0.05), MIC was 3.1% and MGC was 6.3%, inhibition intensity of Hpylori was . Conclusion: Si Kang Shen Nong Yang Sheng Pian tablet has obvious effects of anti-gastric ulcers.