应用血清西司他汀浓度测定肾小球滤过率的相关研究

Correlative study in the measurement of glomerular filtration rate using serum cystatin C Concentration

目的 提供临床上准确、简便测定肾小球滤过率的方法。方法 应用乳胶颗粒增强比浊法（ＰＥＴ）测定 ７９例有肾脏损害患者血清西司他汀（ｃｙｓｔａｔｉｎ Ｃ）浓度，同时测定血尿素氮（ＢＵＮ）、血肌酐（Ｓｃｒ）、２４ ｈ肌酐清除率（２４ ｈ Ｃｃｒ）和采用 Ｃｏｃｋｃｒｏｆｔ－Ｃａｕｌｔ公式计算肌酐清除率（Ｃｃｏｃｋｃｒｏｆｔ）。结果除 ＢＵＮ外，以上指标与 ｅｃｕｓｔａｔｉｎＣ均有相关关系，并有显著性意义。结论 ｃｕｓｔａｔｉｎＣ 浓度检测在临床上提供一种快速、准确和简捷的测定肾小球滤过率的方法，能发现早期肾脏损害和肾功能改变。

Objective To offer an adequate and simple measurement of glomerular filtration rate (GFR)clinically. Methods Serum samples were obtained from 79 cases with renal damage. Serum cystatin C concentration was determined using latex particle enhanced turbidimetrv(PET). BUN, Scr and 24-hour creatinine clearance(24 h Ccr) were determined simultaneously using routine methods. Creatinine clearance was also estimated by Cockcroft-Cault formula(Ccockcroft). Results Except BUN. Scr. 24 h Ccr and Ccockcroft were all correlated with cystatin C concentration significantly. Conclusion Serum cystatin C concentration determination is a rapid. accurate and simple measurement of CFR and can show early renal damage clinically.