宫腔镜下输卵管插管注入甲氨蝶呤治疗输卵管妊娠的临床疗效观察

Clinical efficacy of hysteroscopic tubal intubation methotrexate injection in the treatment of tubal pregnancy

目的评价官腔镜下输卵管插管注入甲氨蝶呤治疗输卵管妊娠的临床疗效。方法；选取2010年1月至2013年10月我院收治的输卵管妊娠患者63例，随机分为两组，其中观察组32例，采用宫腔镜下输卵管插管注入甲氨蝶呤治疗，对照组31例，采用甲氨蝶呤单次肌肉注射治疗。观察并比较两组患者的临床疗效、各指标变化及药物毒副反应发生率。结果观察组治愈率为93．75％，对照组治愈率为74．19％，两组治愈率比较差异有统计学意义（P〈0．05）；两组血HCG恢复正常的时间相比差异有统计学意义（P〈0．05），两组附件区包块消失时间相比差异无统计学意义（P〉0．05）。两组不良反应相比差异有统计学意义（P〈0．05）。结论官腔镜下输卵管插管注入甲氨蝶呤治疗输卵管妊娠的临床疗效好、毒副作用小，值得在临床上予以推广。

Objective To evaluate the clinical efficacy of hysteroscopic tubal intubation methotrexate injection in the treatment of tubal pregnancy. Methods 63 cases of tubal pregnancy were randomly divided into observation group （32 cases） and control group （31 cases） in our hospital from January 2010 to October 5013. Observation group used hysteroscopic tubal intubation methotrexate injection, while control group usedsingle methotrexate intramuscular injection. Clinical efficacy, indexes change and the incidence of drug toxicity were compared between two groups. Results The cure rate in observation group was 93.75%, and that in control group was 74.19%, with statistically significant difference between two groups （P 〈 0.05）. There was statistically significant difference in time of serum HCG returning to normal between two groups （P 〈 0.05）, without statistically significant difference in attachment area mass disappearance time （P 〉 0.05）, with statistically significant difference in adverse reactions （P 〈 0.05）. Conclusion Hysteroscopic tubal intubation methotrexate injection in the treatment of tubal pregnancy is effective, with less drug side effects, worthy of clinical promotion.