辛伐他汀治疗老年高脂血症的使用剂量及其疗效研究

Dosage and efficacy of simvastatin for hyperlipidemia in elderly patients

目的探讨辛伐他汀治疗老年高脂血症的使用剂量及疗效。方法将94例老年高脂血症患者随机分为大剂量组和小剂量组，各47例，分别给予20mg/d与10mg／d辛伐他汀治疗，观察两组治疗疗效。结果大剂量组治疗后各血脂指标均优于小剂量组（P〈0．05）；大剂量组治疗总有效率为95．74％，显著高于小剂量组的82．98％（P〈0．05）；两组患者不良反应发生率比较，差异无统计学意义（P〉0．05）。结论大剂量（20mg／d）辛伐他汀治疗老年高脂血症疗效显著，安全性好。

Objectives To explore the dosage and efficacy of simvastatin for hyperlipidemia in elderly patients. Methods 94 elderly hype,＇lipidemia patients were randomly divided into a large dosage group and a small dosage group, 47 cases for each group. These two groups were treated with simvastatin 20 mg/d and 10 mg/d, respectively. The efficacies of both groups were observed. Results All lipid indicators were enormously better in the large dosage group than in the small dosage group after the treatment （P 〈 0.05 ） . The efficacy was 95.74% in the large dosage group and was 82.98% in the small dosage group （P 〈 0.05 ） . There was no statistical difference in the incidence of adverse reactions between the two groups （ P 〉 0.05 ） . Conclusions Large dosage （ 20 mg/d ） of simvastatin for elderly hyperlipidemia patients is quite effective and safe.