藿香正气水中陈皮渗漉工艺的优化

Optimation of infiltration process of Pericarpium Citri Reticulatae in Huoxiang Zhengqi Liquid

目的优化藿香正气水中陈皮渗漉工艺。方法以橙皮苷的溶出量为指标进行评价,通过单因素试验和正交试验考察影响陈皮渗漉效果的浸泡时间、药材粉碎细度、药材压实程度、渗漉速度、药材浸润与否等工艺参数,并考虑实际工业生产时的生产效率,确定最佳条件。结果藿香正气水中陈皮渗漉的最优化工艺条件:陈皮装罐时要平铺均匀,适当压实;陈皮装罐前不需浸润;浸泡时间24 h与48 h无差别;药材细度在表面积为0.5 cm×0.5 cm左右为最优;陈皮在渗漉时,浸泡溶剂60%乙醇为最佳;在浸泡时溶剂加入量不能太多,以刚没过药材为最优;渗漉时加入溶剂保持上面流速与下面渗漉速度一致为最优;渗漉速度以初漉液渗速约1 mL/(min·kg),续漉液渗速约2 mL/(min·kg)为最优。结论通过以橙皮苷的溶出量为评价指标,确定了藿香正气水中陈皮渗漉的最优化工艺条件。

Objective To optimize the infiltration process of Pericarpium Citri Reticulatae （PCR） in Huoxiang Zhengqi Liquid （HZL）. Methods Using the dissolution content ofhesperidin as indicator, the infiltration process parameters for PCR such as soaking time, fineness of grind, degree of compaction, infiltration rate, and medicinal infiltration or not were studied, and considering the actual production efficiency, the optimal process conditions were determined. Results The optimal infiltration process conditions were as follows： PCR was loaded into the extraction tank without soaking （there was no difference between 24 and 48 h of soaking time）, spread evenly and compacted properly; The crude medicine fineness was about 0.5 cm × 0.5 cm; The infiltration solvent was 60% ethanol; The infiltration solvent was added to the extraction tank of crude medicines, the volume of solvent can not be too much, just inundating crude medicines; Adding solvent speed and infiltration speed were basically identical; The primary infiltration speed was 1 mL/（min·kg） and the continued infiltration speed was 2 mL/（min·kg）. Conclusion The optimal PCR infiltration process conditions of HZL are determined by evaluating the dissolution content of hesperidin.