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黄连素治疗阿尔茨海默病的研究进展 被引量：13

Research progress on treatment of Alzheimer's disease by berberine
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摘要 阿尔茨海默病(Alzheimer’s disease,AD)是一种中枢神经系统退行性疾病,以学习、记忆能力减退和认知功能障碍为主要临床表现。β淀粉样蛋白(Aβ)毒性级联损伤及Tau蛋白的磷酸化是其主要病理改变。黄连素(小檗碱)是从黄连中提取的一种天然的异喹啉类生物碱,具有广泛的药理作用。实验研究表明,黄连素具有抗炎、抗氧化应激、抑制胆碱酯酶活性、抑制Aβ蛋白聚集和Tau蛋白的过度磷酸化等作用。综述近年来黄连素治疗AD的研究进展,以期为黄连素治疗AD提供借鉴。
作者 左茹 曹雪滨 张文生
机构地区 北京师范大学中药资源保护与利用北京市重点实验室 中国人民解放军第 河北大学中医学院
出处 《中草药》 CAS CSCD 北大核心 2014年第8期1184-1187,共4页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目(81274118)
关键词 黄连素 小檗碱 阿尔茨海默病 Β淀粉样蛋白 TAU蛋白 炎症 berberine Alzheimer＇s disease amyloid β-protein Tau protein inflammation
分类号 R285 [医药卫生—中药学]
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参考文献29

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  • 3Asai M, Iwata N, Yoshikawa A, et al. Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion [J]. Biochem Biophys Res Commun, 2007, 352(2): 498-502.
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二级参考文献52

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  • 6Asai M,Iwata N,Yoshikawa A,et al.Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Abeta secretion[J].Biochem Biophys Res Commun,2007,352 (2):498-502.
  • 7Zhu F,Qian C.Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease[J].BMC Neurosci,2006,7:78.
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共引文献35

同被引文献176

引证文献13

二级引证文献120

中草药
2014年 第8期

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