鼠曲草的化学成分研究

Chemical constituents from Gnaphlium affine

目的研究鼠曲草Gnaphlium affine全草化学成分。方法运用多种色谱技术分离鼠曲草全草中黄酮苷类成分,采用波谱技术和理化性质确定化合物的结构。结果从鼠曲草全草70%乙醇提取物中分离得到15个化合物,分别鉴定为3-methoxyphenol1-O-α-L-rhamnopyranosyl-(1→6)-O-β-D-glucopyranoside(1)、3′,5-dihydroxy-2-(4-hydroxybenzyl)-3-methoxybibenzyl(2)、大黄素甲醚(3)、松柏醛(4)、木犀草素-4′-O-β-D-葡萄糖苷(5)、款冬二醇3-O-棕榈酸酯(6)、白桦脂酸(7)、伞形香青酰胺(8)、对羟基桂皮酸甲酯葡萄糖苷(9)、valene-1(10)-ene-8,11-diol(10)、longumoside A(11)、大海米菊酰胺K(12)、槲皮素-3-O-芸香糖基-7-O-葡萄糖苷(13)、木犀草素-7-O-β-D-葡萄糖基-(1→6)-[(6′′′-O-咖啡酸)-β-D-葡萄糖苷](14)、毛蕊花苷(15)。结论化合物1、11为首次从该属植物中得到,化学物2、3、6、8、13、14为首次从该植物中分离得到。

Objective To investigate the chemical constituents from the stems of Gnaphlium affine. Methods Theconstituentswere isolated and purified by silica gel, Sephadex LH-20 column chromatography, and preparative TLC. The structures were identified on the basis of spectral data and physiochemical characteristics. Results Fifteen compounds were isolated from 70% ethanol extracts of G. affine and identified as 3-methoxyphenoll-O--L-rhamnopyranosyl-（1→6）-O-β-D-glucopyranoside （1）, 3＇, 5-dihydroxy-2-（4- hydroxybenzyl）-3-methoxybibenzyl （2）, physcion （3）, aldehyde （4）, luteolin-4＇-O-β-D-glucoside （5）, faradiol 3-O-palmitate （6）, betulinic acid （7）, anabellamide （8）, 4-O-D-glucopyranosyl-p-coumaric acid methyl ester （9）, valene-1 （10）-ene-8, ll-diol （10）, longumoside A （11）, grossamiade K （12）, quercetin-3-O-rutin-7-O-glucoside （13）, luteolin-7-O-β-D-glucopyranosyl-（1→6）-[（6m- O-caffeoylquinic）-β-D-glucopyranoside] （14）, and isoverbascoside （15）. Conclusion Compounds 2 and 11 are reported from the plants in Gnaphalium L. for the first time. Compounds 2, 3, 6, 8, 13, and 14 are isolated from this plant material for the first time.