摘要
Ternary solid complex was synthesized via hybridization of curcumin（Cur）, hydroxyapatite（HAP）, lanthanum（La） and acetic acid（HAc）. The nano-scale hybrid composite of La-Cur/HAP was directly prepared by the wet method. The morphologies and structures of the composite were characterized by scanning electron microscopy （SEM）, infrared（IR） spectroscopy, X-ray diffraction（XRD）, transmission electron microscopy（TEM） and energy dispersive X-ray spectroscopy. The antibacterial activities were tested by methods of minimum inhibitory concentration （MIC） and minimum bactericidal concentration（MBC）. The results show that the size of the La-Cur/HAP composite is less than 100 nm, and the composite exhibits strong bacteriostatic activity against Escherichia coli（E, colt） and Staphylococcus aureus（S, aureus） at low concentrations（in the range of 26-92μg/mL）. The composite can exhibit both of the bacteria and shows higher antibacterial activity against S. aureus than against E. colt. At the same time, La-Cur/HAP shows stronger antibacterial efficiency than ampicillin/HAP.
Ternary solid complex was synthesized via hybridization of curcumin（Cur）, hydroxyapatite（HAP）, lanthanum（La） and acetic acid（HAc）. The nano-scale hybrid composite of La-Cur/HAP was directly prepared by the wet method. The morphologies and structures of the composite were characterized by scanning electron microscopy （SEM）, infrared（IR） spectroscopy, X-ray diffraction（XRD）, transmission electron microscopy（TEM） and energy dispersive X-ray spectroscopy. The antibacterial activities were tested by methods of minimum inhibitory concentration （MIC） and minimum bactericidal concentration（MBC）. The results show that the size of the La-Cur/HAP composite is less than 100 nm, and the composite exhibits strong bacteriostatic activity against Escherichia coli（E, colt） and Staphylococcus aureus（S, aureus） at low concentrations（in the range of 26-92μg/mL）. The composite can exhibit both of the bacteria and shows higher antibacterial activity against S. aureus than against E. colt. At the same time, La-Cur/HAP shows stronger antibacterial efficiency than ampicillin/HAP.
基金
Supported by the Technology Development Project Foundation of Jilin Province, China（Nos.20110940, 20130413059GH） and the 50th Post Doctor Science Foundation of China（No.2011M500600）.
