乙酰乙酸酯法合成假性紫罗兰酮同分异构体温度反应行为研究

Study on reaction temperature behavior for the synthesis of pseudoionone isomers by methyl acetoacetate method

对乙酰乙酸甲酯与去氢里哪醇反应合成假性紫罗兰酮体系的反应物热稳定性和反应温度行为进行研究 ,着重对 413 15～ 44 3 15K温区内假性紫罗兰酮同分异构体的初始生成速率进行动态化学研究 ,得到对应的Arrhenius反应活化能△H1=36 5 6 6kJ/mol、△H2 =2 2 1 0 7kJ/mol、△H3 =15 8 17kJ/mol;并确定了该反应体系以生成假性紫罗兰酮为目标产物的适宜反应温度控制在 44 3 15K左右。

The experiments are carried out to investigate the reactants thermostability and the reaction temperature behavior in the synthesis of pseudoionone isomers by use of methyl acetoacetate and dehydrolinalool, specially to investigate the initial creating rate of the isomers in the temperature zone of 41315K～44315K to get the Arrhenius activation energies with respect to the isomers (ΔH_1=36566kJ/mol,ΔH_2=22107kJ/mol,ΔH_3=15817kJ/mol)In a result, the appropriate temperature about 44315K for the synthesis of the target product pseudoionone is obtained in the reaction system The results can be used to guide the engineering development for the synthesis of pseudoionone by this method