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B7-H4与肾移植术后肿瘤

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摘要 B7-H4是B7-CD28家族的新成员,可降低肾移植术后T细胞介导的排斥反应,同时大量B7-H4表达可促进上皮细胞的恶性转化,保护上皮细胞免于失巢凋亡,出现肾移植术后肿瘤,提示B7-H4可能在肿瘤的发生、进展及预后中发挥着直接及间接的作用。局部诱导B7-H4表达并选择性封闭B7-H4导致肿瘤的信号通路,有望延长移植肾存活时间,并能够预防恶性肿瘤的发生。
出处 《现代医学》 2014年第5期585-589,共5页 Modern Medical Journal
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