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白细胞介素18研究进展 被引量:5

Research Advances for Interleukin-18
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摘要 白细胞介素18(IL-18)作为疫苗的高效免疫增强剂,能大幅度提高疫苗的免疫保护率和机体的免疫水平,成为近年来DNA疫苗研究领域的热点之一。文章概述了IL-18的发现与分布、分子特性、生物学作用以及在兽用疫苗中的应用等方面的研究进展。 Lnterleukin -18 (IL -18 ) as vaccine effective immune enhancement can greatly improve the vaccine immune protection and immune lev- els and has become one of thehotspots in the DNA vaccine research. This article provides an overview of IL - 18 discovery and distribution, molecular properties, biological function and other aspects of the application of animal vaccine development.
出处 《贵州畜牧兽医》 2014年第2期21-24,共4页 Guizhou Journal of Animal Husbandry & Veterinary Medicine
关键词 IL-18 免疫佐剂 兽用疫苗 IL-18 Immune Adjuvant Veterinary Vaccines
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  • 1Okmura H ,Tsutsui H , komatsu T. Cloning of a new cy- tokine that induces IFN - production by T cell [ J ]. Nature, 1995, (378) : 88 - 91.
  • 2Ushio S, Namba M, Okura T, et al. cDNA cloning of the cDNA for human IFN - gamma - inducing factor, expres- sion in Escherichia coli and studies on the biologic activi- ties of the protein[ J ]. Immuno, 1996,156 (9):4 274- 4 279.
  • 3Shen G S, Jin N Y, Ma M X, et al. Immune responses of pigs inoculated with a recombinant fowlpox virus coex-pressing GP5/GP3 of porcine reproductive and respiratory syndrome virus and swine IL- 18 [J].Vaccine ,2007,25: 4 193 -4 202.
  • 4Taniguchi M, Nagaoka K, Kunikata T, et al, Cheracter- ization of anti - human interleukin - 18 ( IL - 18 ) interfer- on - gamma - inducing factor ( IGIF ) monoclonal anti- bodies and their application in the measurement of human IL - 18 by ELISA[ J]. Immunol Methods, 1997,206 : 107.
  • 5Lertmemongkolchai G, Cai G, Hunter C A, et al. By- stander activation of CD8 + T cells contributes to the rap- id production of IFN - gamma in response to bacterial Pathogens [ J]. Immunol,2001,166 ; 1097.
  • 6Okamura H,Nagata K, Komatsu T, et al. A novel costim- ulatory factor for Gamma interferon induction found in the livers of mice causes endotoxic shock [ J ]. Infect Immun, 1995,63(10) :3 966 -3 972.
  • 7Dao T,ohashi K, Kayano T, et al. Interferon - γ inducing factor a novel cytokine Enhances Fas ligard - mediate cy- totocieity of murine T helper 1 cells [ J ]. Cell Inununol, 1996,173 (2) :230 - 235.
  • 8Tsutsui H, Nakanisht K,Matsui K,et al. Inununol, 1996. 157(9) :3 967 -3 973.
  • 9Takeda K, Tsutsui H, Yoshimoto T, et al. Defective NK cell activity and Thl response in IL - 18 - deficient mice [ J ]. Immunity, 1998, (3) :383 - 390.
  • 10张洪勇,金宁一,尹革芬,等.以猪白介素18为细胞因子佐剂与口蹄疫病毒P1-2A重组核酸疫苗的联合免疫[C].中国畜牧兽医学会家畜传染病学分会成立20周年庆典暨第十次学术研讨会论文集,2003.1065-1067.

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