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意义未明的单克隆丙种球蛋白血症和冒烟型骨髓瘤：生物学特征与早期治疗策略

Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma： biological insights and early treatment strategies
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摘要 尽管意义未明的单克隆丙种球蛋白血症（MGUS）与冒烟型骨髓瘤（SMM）在人群中的发生率并不低，但是相关研究较少。文章对MGUS／SMM的生物学研究进展进行了概述，并讨论了MGUS／SMM的危险分层、标志物与高危SMM（早期多发性骨髓瘤）患者的早期治疗策略。 Researches on monoclonal gammopathy of undetermined significance （MGUS） and smoldering multiple myeloma （SMM） are at a low level although their incidence is high. This review discusses current biological insights in MGUS/SMM and discusses how the integration of novel biological markers, molecular imaging, and clinical monitoring of MGUS/SMM could facilitate the development of early treatment strategies for high-risk SMM （early myeloma） patients in the future.
作者 菅原 严冬 陈文明
机构地区 首都医科大学附属北京朝阳医院血液科北京市多发性骨髓瘤医疗研究中心 首都医科大学附属北京朝阳医院肿瘤科 北京市多发性骨髓瘤医疗研究中心
出处 《白血病．淋巴瘤》 CAS 2014年第5期257-260,共4页 Journal of Leukemia & Lymphoma
基金 国家自然科学基金（81172252） 首都临床特色应用研究专项（Z131107002213146）
关键词 多发性骨髓瘤 意义未明的单克隆丙种球蛋白血症 冒烟型骨髓瘤 Multiple myeloma Monoclonal gammopathy of undetermined significance Smoldering multiple myeloma
分类号 R733.7 [医药卫生—肿瘤] R733.3 [医药卫生—肿瘤]
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参考文献29

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白血病．淋巴瘤
2014年 第5期

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