外周血钙卫蛋白、环氧化酶-2水平变化与动脉血栓性疾病的关系

Relationship between S100A8/A9, COX-2 levels of peripheral blood and arterial thrombotic disease

目的 探讨外周血钙卫蛋白（S100A8/A9）、环氧化酶-2（COX-2）水平与动脉血栓性疾病的关系及其临床意义.方法 选取动脉血栓性疾病患者101例,其中急性心肌梗死患者50例,冠心病患者51例.25例健康体检者为对照组.采用酶联免疫吸附法（ELISA）检测各组血清S100A8/A9、COX-2水平,并分析S100A8/A9、COX-2水平间的相关性.结果 （1）动脉血栓性疾病患者外周血S100A8/A9、COX-2水平明显高于对照组;（2）急性心肌梗死组患者S100A8/A9、COX-2水平明显高于冠心病组;（3）急性心肌梗死组和冠心病组S100A8/A9水平与COX-2水平均无明显相关性.结论 心血管病患者外周血S100A8/A9、COX-2水平明显升高可能与疾病的发生、发展相关;S100A8/A9、COX-2可作为判断动脉血栓性疾病严重程度的参考指标之一.

Objective To observe S100A8/A9,COX-2 levels in patients with arterial thrombotic disease and evaluate their relationships with arterial thrombotic diseases and their clinical significance.Methods There were 101 patients with arterial thrombotic disease in experimental group,including 50patients with acute coronary syndrome,51 patients with coronary heart disease.There were 25 cases in normal controls.Enzyme-linked immunosorbent assay ELISA was used to detect and compare the serum levels of S100A8/A9 and COX-2.Then the relevance between S100A8/A9 and COX-2 levels was tested.ELISA was used to analyze the expression of S100A8/A9,COX-2 in different groups.Results （1） The levels of S100A8/A9 and COX-2 in patients with arterial thrombotic disease were significantly higher.（2）The levels of S100A8/A9 and COX-2 in acute coronary syndrome group were significantly higher than CHD group.（3）There were no significant relevance between S100A8/A9 and COX-2 levels in both acute coronary syndrome group and CHD group.Conclusion Significantly elevated S100A8/A9,COX-2 levels in patients undergo cardiovascular disease may associate with the development of the disease.S100A8/A9,COX-2 can be used as a reference to judge the severity of arterial thrombotic disease.