续断的化学成分研究

Chemical constituents of Dipsaci Radix

目的研究续断的化学成分。方法运用大孔树脂、反相硅胶及制备高效液相等色谱技术进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果分离得到13个化合物,其中7个环烯醚萜苷和6个木脂素类化合物,分别鉴定为马钱苷(1)、獐牙菜苷(2)、6'-O-β-D-apiofuranosyl-sweroside(3)、续断苷H(4)、续断苷F(5)、续断苷E(6)、triplostoside A(7)、(7R,8S,7'R,8'S)-5-methoxyprinsepiol-4-O-β-D-glucopyranoside(8)、(7R,8S,7'R,8'S)-prinsepiol-4-O-β-D-glucopyranoside(9)、acanthoside D(10)、(7R,8S,7'R,8'S)-fraxiresinol-4'-O-β-D-glucopyranoside(11)、(7R,8S,7'R,8'S)-8-hydroxypinoresinol-4'-O-β-D-glucopyranoside(12)、(7R,8S,7'R,8'S)-8-hydroxypinoresinol-4-O-β-D-glucopyranoside(13)。结论其中化合物8、9、11、12、13为首次从川续断属植物中分离得到。

Objective To study the chemical constituents of Dipsaci Radix. Methods The compounds were isolated by macroporous resin, reverse phase Cl8 silica gel, and semi-prepative HPLC. Their structures were identified on the basis of physicochemical properties and spectroscopic data. Results Thirteen compounds were separated, seven of which were iridoid glycosides, and six of which were lignans, identified as loganin （1）, sweroside （2）, 6＇-O-β-D-apiofuranosyl-sweroside （3）, dipsanoside H （4）, dipsanoside F （5）, dipsanoside E （6）, triplostoside A （7）, （7R, 8S, 7＇R, 8＇S）-5-methoxyprinsepiol-4-O-β-D-glucopyranoside （8）, （7R, 8S, 7＇R, 8＇S）-prinsepiol-4-O-13-D-glucopyranoside （9）, acanthoside D （10）, （TR, 8S, 7＇R, 8＇S）-fraxiresinol-4＇-O-13-D-glucopyranoside （11）, （7R, 8S, 7＇R, 8＇S）-8-hydroxypinoresinol-4＇-O-β-D-glucopyranoside （12）, and （7R, 8S, 7＇R, 8＇S）-8-hydroxypinoresinol-4-O-β-D- glucopyranoside （13）, respectively. Conclusion Compounds 8, 9, and 11-13 are isolated from this genus for the first time.