微量白蛋白尿对于IgA肾病患者的临床、病理研究

Clinicopathological study of IgA nephropathy patients with microalbuminuria

目的总结表现为微量白蛋白尿的IgA肾病(IgAN)患者的临床及病理的特点,探讨微量白蛋白尿对于IgAN的病理改变及预后的影响。方法对90例微量白蛋白尿IgAN患者的临床和病理资料进行回顾性分析,探讨其相关性。结果 90例临床表现为微量白蛋白尿的IgAN患者中,14例(15.6%)存在肾功能异常,18.4%的肾功能正常的患者中存在LeeⅢ级以上的病理损害,多因素logistic回归分析显示微量白蛋白尿是IgAN病理损伤的独立危险因素。结论微量白蛋白尿是IgAN病理损伤的独立危险因素,临床表现为微量白蛋白尿的IgAN患者的病理损伤亦可能较重,微量白蛋白尿可影响IgAN患者的预后。

Objective：To Summarize the clinicopathological features of IgA nephrology（ IgAN）patients with microalbu-minuria and investigate the influence of microalbuminuria to IgA nephropathy pathological changes and prognosis. Methods：The clinical and pathological data of all IgAN patients with microalbuminuria was retrospectively analyzed,to discuss the correlation. Results：14 cases（15. 6%）of IgA nephrology（IgAN）patients with clinical manifestations included microalbu-minuria existed abnormal renal function,18. 4% of patients with normal renal function existed pathological damage accord-ing with Lee’s grade Ⅲ or more severe. Multifactor logistic regression analysis revealed that microalbuminuria was inde-pendent risk factors for renal pathological lesions of IgA nephropathy. Conclusions：Microalbuminuria is independent risk factors for renal pathological lesions of IgA nephropathy,severe renal histological injury may be seen in some IgAN patients with microalbuminuria,and microalbuminuria effects the prognosis of these patients.