香菇多糖及胸腺五肽注射液在颈淋巴结转移性口腔鳞癌术后辅助化疗中的应用

APPLICATION OF LENTINAN AND THYMOPENTIN AS ADJUVANT CHEMOTHERAPY IN ORAL SQUAMOUS CELL CARCINOMA WITH METASTATIC CERVICAL LYMPH NODE AFTER SURGERY

目的观察顺铂+替尼泊甙+平阳霉素/博莱霉素(PTP)化疗方案与香菇多糖及胸腺多肽联合治疗口腔鳞癌术后伴淋巴结转移患者的疗效及不良反应。方法口腔鳞癌患者96例随机分为4组,A组23例单纯给予PTP方案化疗治疗,B组26例给予香菇多糖注射液联合PTP化疗方案治疗,C组19例给予胸腺五肽注射液联合PTP化疗方案治疗,D组28例给予香菇多糖及胸腺五肽注射液联合PTP化疗方案治疗。检测化疗前后患者血清中肿瘤特异性生长因子(tumor specific growth fanctor,TSGF)、免疫指标的表达,并监测不良反应,评价疗效。结果 D组TSGF表达及不良反应均低于另外3组,差异有统计学意义(P<0.05)。D组细胞免疫各项指标及体液免疫中的IgG均优于A、B、C组,差异有统计学意义(P<0.05);而IgA和IgM各组差异无统计学意义(P>0.05)。结论香菇多糖及胸腺五肽注射液联合PTP化疗方案对改善口腔鳞癌的预后及减少不良反应的发生有明显效果。

Objective The study was to explore cisptatin ＋ teniposide ＋ pingyangmycin/ bleomycin （PTP） chemotherapy with lentinan and thymic peptide injection combined treatment of oral squamous cell carcinoma with lymph node metastasis in patients with postoperative efficacy and adverse reactions. Methods Ninety-six patients with oral squamous cell carcinoma were randomly divided into four groups, group A 23 patients given PTP chemotherapy treatment alone, group B 26 patients lentinan injection combined with chemotherapy in the treatment PTP, group C 19 patients thymopentin PTP injection combined with chemotherapy regimens, D group 28 patients lentinan and thymic injection combined with chemotherapy in the treatment of five PTP peptide detected after treatment with chemotherapy before and after serum tumor specific growth factor （tumor specific growth factor, TSGF） expression and adverse reactions, and to evaluate its efficacy. Results TSGF expression and adverse reactions in group D were significantly lower than those of the other three groups （ P 〈 0.05 ）, ceuimmune function indicators and the indicator of IgG in group D were better than A, B, C groups （ P 〈 0.05 ） , IgA, IgM indicators in four groups before and after treatment showed no significant difference （ P 〉 0.05 ）. Conclusion Lentinan injection and thymopentin FTP injection combined with PTP chemotherapy improved the prognosis of oral squamous cell carcinoma and reduced the incidence of adverse reactions obviously.