视黄醇结合蛋白4对肾脏疾病早期诊断的评估

Retinol Binding Protein4 Assessment of the Early Diagnosis of Kidney Disease

视黄醇结合蛋白4(RBP4)是一类合成于肝脏且广泛分布于人体血液、尿液等其它体液中的维生素A运载蛋白,它在协助维生素A发挥生理功能中起着决定性的作用。近年来的研究表明:当近端肾小管受损时,人体血液或尿液中视黄醇结合蛋白4的含量会出现不同程度的升高。同时它与糖尿病肾病、营养性疾病的发展等其它疾病都在临床上存在着一定的相关性。临床上已将RBP4的含量测定作为判定肾功能有效且成熟的指标之一。目前临床上对视黄醇结合蛋白4的检测主要是传统的酶联免疫法、免疫比浊法等,近年来随着研究水平的不断提高,对RBP4的检测方法已有逐渐转向新型的快速检测方法的趋势。本文在对视黄醇结合蛋白4的理化性质、在肾脏等各类疾病方面的应用以及新型临床检测方法等方面作一综述,随着研究的不断完善,视黄醇结合蛋白4的更多临床意义将逐渐显现。

Retinol-binding protein 4 （RBP4） is a class of synthesis in the liver and widely distributed in the vitamin A in human blood, urine and other body fluids carrying protein, and it is to play in assisting vitamin A plays a decisive role in the physiological functions. Recent studies show that： when proximal tubular damage in human blood or urine retinol binding protein 4 content there will be different degrees. While its other diseases and diabetic nephropathy, and the development of nutritional diseases in clinical practice the existence of certain correlation. Assaying of RBP4 has been set as one of the effective maturity indicators to determine renal function. Clinical detection ofretinol binding protein 4 main traditional enzyme-linked immunosorbent assay, immune turbidimetric method, along with the increasing levels of research in recent years RBP4 detection has gradually turned to a new rapid detection method. In this paper, the physical and chemical properties of retinol-binding protein 4 in the kidneys and other types of diseases, and new clinical detection methods are reviewed, along with the constant improvement of the study, retinol binding protein 4 more clinical significance will gradually emerge.